SAB4200205
Anti-Tensin 3 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-TEM6, Anti-TNS3, Anti-Tensin-like SH2 domain-containing protein 1, Anti-Tumor endothelial marker 6
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~180 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
western blot: 1.5-3.0 μg/mL using HEK-293T cell lysates over expressing human tensin 3.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TNS3(64759)
General description
Tensin 3 is expressed in various tissues such as thyroid, kidney and placenta and different cell types including endothelial, epithelial cells and fibroblasts.
Tensin-3 gene (TNS3) is located on human chromosome 7p12.3. TNS3 has N-terminal actin-binding domain and C-terminal sarcoma (Src) homology 2 (SH2) domain and a phosphotyrosine binding (PTB) domain.
Application
Anti-Tensin 3 (C-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Anti-Tensin3 (C-terminal) specifically recognizes human tensin 3.
Tensin 3 contributes to cell migration and tumorigenesis in cell lines from advanced lung cancer, breast cancer and melanoma.
Tensin-3 (TNS3) plays a key role in cell adhesion and migration by crosslinking actin to adhesion proteins like integrin. Phosphorylation of tensin-3 by sarcoma (Src) tyrosine kinase is observed in carcinomas. Downregulation of tensin-3 is implicated in the metastatic behavior of human kidney carcinoma. Knockdown of TNS3 gene impairs adhesion and migration of breast cancer cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
Vess A, et al.
Journal of Cell Science, 16(3), jcs-200899 (2017)
Tensin3 is a novel thyroid-specific gene
Maeda I, et al.
Journal of Molecular Endocrinology, 36(1), R1-R8 (2006)
CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma
Carter JA, et al.
Epigenetics, 8(7), 739-747 (2013)
Epidermal Growth Factor Modulates Tyrosine Phosphorylation of a Novel Tensin Family Member, Tensin311Supported in part by the Shriners Hospitals Research Award and NIH CA102537.
Cui Y, et al.
Molecular Cancer Research, 2(4), 225-232 (2004)
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis
Qian X, et al.
Cancer Cell, 16(3), 246-258 (2009)
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