Anti-Dystrobrevin-β (N-terminal) antibody produced in rabbit

The dystrobrevin-β(DTNB) gene is mapped to human chromosome 2p23.3. The encoded protein belongs to the dystrobrevin (DB) subfamily of the dystrophin-related protein family. DB is a component of the dystrophin-glycoprotein complex (DGC) that is located at the muscle sarcolemma and forms a transmembrane link between the cytoskeleton and the basal lamina. β-DB is confined to non-muscle tissues and predominantly expressed in the kidney and brain. β-DB is linked to dystrophin and syntrophin isoforms in the hippocampus, cortex, and Purkinje cells. It is abundant in the post-synaptic densities (PSDs).

synthetic peptide corresponding to a sequence located at the N-terminus of human dystrobrevin-b (DTNB), conjugated to KLH. The corresponding sequence is identical in human DTNB isoforms 1-5, and highly conserved (single amino acid substitution) in rat and mouse DTNB.

Anti-Dystrobrevin-β (N-terminal) antibody produced in rabbit is suitable for:

• immunoblotting
• immunofluorescence
• immunohistochemistry

Anti-Dystrobrevin-b(N-terminal) specifically recognizes human and rat dystrobrevin-b.

Dystrobrevin-β (β-DB) may be significantly involved in assembling and supporting the dystrophin-associated protein complex (DPC)-like complexes in non-muscle tissues. It is known to interact with the neuronal kinesin heavy chain Kif5A and Kif5B in the brain, suggesting that β-DB might act as a motor protein receptor involved in the transport of dystrophin-glycoprotein complex (DGC) components to specific sites in the cell.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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