SAB4200397
Anti-EXOSC4 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody
别名:
Anti-Exosome complex component, Anti-Exosome complex exonuclease RRP41, Anti-Exosome component 4, RRP41, Anti-RRP41, Anti-RRP41A, Anti-Rrp41p, Anti-SKI6, Anti-Ski6p, Anti-hRrp41p, Anti-p12A
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
分子量
antigen ~26 kDa
种属反应性
human, mouse
浓度
~1 mg/mL
技术
immunoprecipitation (IP): 2.5-5 μg using lysates of human HeLa cells
indirect immunofluorescence: 5-10 μg/mL using human HeLa cells
western blot: 2-4 μg/mL using whole extracts of mouse Hepa1-6 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EXOSC4(54512)
mouse ... Exosc4(109075)
一般描述
Exosome Component 4 (EXOSC4), also known as RNA-processing protein 41 (RRP41), is a non-catalytic component of the eukaryotic RNA exosome. The eukaryotic exosome is a 400kDa complex composed of a nine subunit catalytically inert core provides structural support and facilitates substrate recognition, and two associated catalytic subunits.
The gene EXOSC4 (exosome component 4) is mapped to human chromosome 8q24.3. The encoded protein is present in the cytoplasm as well as nucleus and has a RNase pleckstrin homology (PH) domain.
免疫原
peptide corresponding to the N-terminal region of human EXCSC4, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.
应用
Anti-EXOSC4 antibody produced in rabbit has been used in various immunochemical techniques including immunoblotting, immunoprecipitation and immunofluorescence.
生化/生理作用
EXOSC4 (exosome component 4) is a core component of the exosome complex and is required for the stability of the complex. The exosome complex exhibits 3′-5′ exoribonuclease function. EXOSC4 lacks ribonuclease activity but is involved in mRNA turnover.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
John R Anderson et al.
RNA (New York, N.Y.), 12(10), 1810-1816 (2006-08-17)
We have previously demonstrated that PM-Scl-75, a component of the human exosome complex involved in RNA maturation and mRNA decay, can specifically interact with RNAs containing an AU-rich instability element. Through the analysis of a series of deletion mutants, we
Chang Ohk Sung et al.
Cancer genetics, 206(5), 145-153 (2013-06-04)
Ovarian clear cell adenocarcinoma (Ov-CCA) is a distinctive subtype of ovarian epithelial carcinoma. In this study, we performed array comparative genomic hybridization (aCGH) and paired gene expression microarray of 19 fresh-frozen samples and conducted integrative analysis. For the copy number
Uttiya Basu et al.
Cell, 144(3), 353-363 (2011-01-25)
Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphocytes by deaminating cytidines on template and nontemplate strands of transcribed DNA substrates. However, the mechanism of AID
Erwin L van Dijk et al.
RNA (New York, N.Y.), 13(7), 1027-1035 (2007-06-05)
The human exosome is a 3'-5' exoribonuclease complex that functions both in the nucleus and in the cytoplasm to either degrade or process RNA. Little is known yet about potential differences among core exosome complexes in these different cellular compartments
Rafal Tomecki et al.
The EMBO journal, 29(14), 2342-2357 (2010-06-10)
The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and turnover. It consists of a nine-subunit catalytically inert core that serves a structural function and participates in substrate recognition. Best defined in Saccharomyces cerevisiae, enzymatic activity comes
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