SAB4200413
Monoclonal Anti-LIN28 antibody produced in mouse
clone L28.5, tissue culture supernatant
别名:
Monoclonal Anti-CSDD1, Monoclonal Anti-LIN28A, Monoclonal Anti-ZCCHC1
生物来源
mouse
偶联物
unconjugated
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
L28.5, monoclonal
表单
buffered aqueous solution
分子量
antigen ~28 kDa
种属反应性
mouse, human
技术
western blot: 1:8,000-1:16,000 using extracts of Ntera-2 cells.
同位素/亚型
IgM
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LIN28A(79727)
mouse ... Lin28a(83557)
一般描述
LIN28 belongs to a family of RNA-binding proteins that are mainly expressed in embryonic stem cells.
免疫原
synthetic peptide corresponding to a sequence at the C-terminus of human LIN28A. The isotype is determined using a double diffusion immunoassay using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).
应用
Monoclonal Anti-LIN28 antibody produced in mouse is suitable for immunoblotting at a working dilution of 1:8000 to 1:16000. For immunofluorescence, a dilution of 1:1500 to 1:3000 is recommended.
Monoclonal Anti-LIN28 antibody produced in mouse specifically recognizes C-terminus of human LIN28A.
生化/生理作用
The structure of LIN28 includes RNA-binding domains, an N-terminal cold-shock domain and a C-terminal Zn-knuckle domain. It inhibits the biogenesis of let-7 miRNA and modulates the translation of target mRNA. The expression of LIN28 is linked to the cellular processes of development, differentiation, oncogenesis and glucose metabolism. It is also linked to the resistance of breast cancer cells to radiation effects.
外形
Solution containing 15 mM sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Florian Mayr et al.
International journal of molecular sciences, 14(8), 16532-16553 (2013-08-14)
Lin28 is an essential RNA-binding protein that is ubiquitously expressed in embryonic stem cells. Its physiological function has been linked to the regulation of differentiation, development, and oncogenesis as well as glucose metabolism. Lin28 mediates these pleiotropic functions by inhibiting
Linbo Wang et al.
PloS one, 8(6), e67373-e67373 (2013-07-11)
Resistance to radiation therapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to breast tumorigenesis; however, the relationship between Lin28 and radioresistance remains unknown. In this study, we investigated the association of
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