跳转至内容
Merck
CN

SAB4200432

Anti-RASD2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-RAS homolog enriched in striatum, Anti-RASD family, member 2, Anti-RHES, Anti-TEM-2

登录 查看组织和合同定价。

选择尺寸

关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
3

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~34 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells overexpressing human RASD2, indirect immunofluorescence: 5-10 μg/mL using HEK-293T cells overexpressing RASD2, western blot: 0.5-1 μg/mL using lysates of HEK-293T cells overexpressing human RASD2

UniProt accession no.

Q96D21

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RASD2(23551)

General description

RASD2 (Ras homolog enriched in striatum) is a member of the family of Ras small G proteins. RASD2 is a 266 amino acid GTP binding protein, which is expressed in the striatum. The gene is located on human chromosome 22 (q12.3).

Immunogen

synthetic peptide corresponding to a sequence near the C-terminus of human RASD2, conjugated to KLH. The corresponding sequence is highly conserved (83% sequence identity) in rat and mouse RASD2.

Application

Anti-RASD2 antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence
  • immunoprecipitation

Biochem/physiol Actions

RASD2 (Ras homolog enriched in striatum) prevents the activation of Gαs and promotes dopamine D2 receptor-mediated activation of Gαi/o. It mediates mammalian target of rapamycin (mTOR) signaling and L-DOPA(L-3,4-dihydroxyphenylalanine)-induced dyskinesia. It is suggested to be the principal determinant of striatal mTOR activation. RASD2 is associated with Huntington′s disease (HD). Rhes-mHtt interaction is implicated in neuropathology of HD in the striatum.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

未找到合适的产品？  

试试我们的产品选型工具.

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
052M4765

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy
Mealer RG, et al.
The Journal of Biological Chemistry, 289(6), 3547-3554 (2014)
Rasd2 modulates prefronto-striatal phenotypes in humans and `schizophrenia-like behaviors? in mice
Vitucci D, et al.
Neuropsychopharmacology, 41(3), 916-916 (2016)
Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy
Mealer RG, et al.
Test (2014)

相关内容

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持