SAB4200432
Anti-RASD2 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-RAS homolog enriched in striatum, Anti-RASD family, member 2, Anti-RHES, Anti-TEM-2
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
分子量
antigen ~34 kDa
种属反应性
human
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells overexpressing human RASD2
indirect immunofluorescence: 5-10 μg/mL using HEK-293T cells overexpressing RASD2
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells overexpressing human RASD2
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RASD2(23551)
一般描述
RASD2 (Ras homolog enriched in striatum) is a member of the family of Ras small G proteins. RASD2 is a 266 amino acid GTP binding protein, which is expressed in the striatum. The gene is located on human chromosome 22 (q12.3).
免疫原
synthetic peptide corresponding to a sequence near the C-terminus of human RASD2, conjugated to KLH. The corresponding sequence is highly conserved (83% sequence identity) in rat and mouse RASD2.
应用
Anti-RASD2 antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunoprecipitation
生化/生理作用
RASD2 (Ras homolog enriched in striatum) prevents the activation of Gαs and promotes dopamine D2 receptor-mediated activation of Gαi/o. It mediates mammalian target of rapamycin (mTOR) signaling and L-DOPA(L-3,4-dihydroxyphenylalanine)-induced dyskinesia. It is suggested to be the principal determinant of striatal mTOR activation. RASD2 is associated with Huntington′s disease (HD). Rhes-mHtt interaction is implicated in neuropathology of HD in the striatum.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy
Mealer RG, et al.
The Journal of Biological Chemistry, 289(6), 3547-3554 (2014)
Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy
Mealer RG, et al.
Test (2014)
Rasd2 modulates prefronto-striatal phenotypes in humans and `schizophrenia-like behaviors? in mice
Vitucci D, et al.
Neuropsychopharmacology, 41(3), 916-916 (2016)
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