主要文件

查看所有文档

SAB4200432

Anti-RASD2 antibody produced in rabbit

Name: Anti-RASD2 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-RAS homolog enriched in striatum, Anti-RASD family, member 2, Anti-RHES, Anti-TEM-2

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Citations:

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~34 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells overexpressing human RASD2, indirect immunofluorescence: 5-10 μg/mL using HEK-293T cells overexpressing RASD2, western blot: 0.5-1 μg/mL using lysates of HEK-293T cells overexpressing human RASD2

UniProt accession no.

Q96D21

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RASD2(23551)

正在寻找类似产品? 访问产品对比指南

General description

RASD2 (Ras homolog enriched in striatum) is a member of the family of Ras small G proteins. RASD2 is a 266 amino acid GTP binding protein, which is expressed in the striatum. The gene is located on human chromosome 22 (q12.3).

Immunogen

synthetic peptide corresponding to a sequence near the C-terminus of human RASD2, conjugated to KLH. The corresponding sequence is highly conserved (83% sequence identity) in rat and mouse RASD2.

Application

Anti-RASD2 antibody produced in rabbit has been used in:

immunoblotting
immunofluorescence
immunoprecipitation

Biochem/physiol Actions

RASD2 (Ras homolog enriched in striatum) prevents the activation of G_αs and promotes dopamine D2 receptor-mediated activation of G_αi/o. It mediates mammalian target of rapamycin (mTOR) signaling and L-DOPA(L-3,4-dihydroxyphenylalanine)-induced dyskinesia. It is suggested to be the principal determinant of striatal mTOR activation. RASD2 is associated with Huntington′s disease (HD). Rhes-mHtt interaction is implicated in neuropathology of HD in the striatum.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

未找到合适的产品？

试试我们的产品选型工具.

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

052M4765

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy

Mealer RG, et al.

The Journal of Biological Chemistry, 289(6), 3547-3554 (2014)

Rasd2 modulates prefronto-striatal phenotypes in humans and `schizophrenia-like behaviors? in mice

Vitucci D, et al.

Neuropsychopharmacology, 41(3), 916-916 (2016)