SAB4200456
Anti-EXOSC7 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-EAP1, Anti-Exosome complex component RRP42, Anti-Exosome complex exonuclease RRP42, Anti-Exosome component 7, Anti-RRP42, Anti-Ribosomal RNA-processing protein 42, Anti-hRrp42p, Anti-p8
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~34 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells, indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa
cells, western blot: 1-2 μg/mL using whole extracts of HEK-293T
cells over-expressing human EXOSC7
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EXOSC7(23016)
General description
Exosome component 7 (EXOSC7) protein is a non-catalytic component of the eukaryotic RNA exosome. The exosome is an evolutionary conserved multisubunit 3′ to 5′ exoribonuclease complex that exists both in the nucleus and cytoplasm. EXOSC7 protein is present at higher levels in epidermal progenitor cells. This protein forms the hexameric ring structure unit of the eukaryotic exosome. EXOSC7 gene is located on the human chromosome 3p21.31.
Immunogen
peptide corresponding to the C-terminal region of human EXOSC7, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and
rat.
rat.
Application
Anti-EXOSC7 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Anti-EXOSC7 (C-terminal) recognizes human EXOSC7.
Exosome component 7 (EXOSC7) is involved in blocking the premature differentiation of progenitor cells. Exosome complex is involved in the degradation and processing of cellular RNA.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Derrick J Morton et al.
PLoS genetics, 16(7), e1008901-e1008901 (2020-07-10)
The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs. The recent discovery that mutations in genes encoding structural RNA exosome subunits cause tissue-specific diseases makes defining the
Ying Liu et al.
Biomedical reports, 8(3), 207-214 (2018-03-31)
Exosomes are one of the most potent intercellular communicators, which are able to communicate with adjacent or distant cells. Exosomes deliver various bioactive molecules, including membrane receptors, proteins, mRNA and microRNA, to target cells and serve roles. Recent studies have
J Prados et al.
Genes, brain, and behavior, 14(2), 177-188 (2015-01-23)
Early life adversity plays a critical role in the emergence of borderline personality disorder (BPD) and this could occur through epigenetic programming. In this perspective, we aimed to determine whether childhood maltreatment could durably modify epigenetic processes by the means
Rafal Tomecki et al.
The EMBO journal, 29(14), 2342-2357 (2010-06-10)
The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and turnover. It consists of a nine-subunit catalytically inert core that serves a structural function and participates in substrate recognition. Best defined in Saccharomyces cerevisiae, enzymatic activity comes
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