SAB4200471
Anti-SND1 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-TDRD11, Anti-staphylococcal nuclease and tudor domain containing 1, p100
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~102 kDa
种属反应性
rat, mouse, human
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 1-2 μg using lysates of rat NRK cells.
indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells
western blot: 0.25-0.5 μg/mL using whole extracts of mouse NIH-3T3 cells.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SND1(27044)
mouse ... Snd1(56463)
rat ... Snd1(64635)
一般描述
Staphylococcal nuclease and tudor domain containing 1 (SND1) protein contains five staphylococcal nuclease-like domains and a tudor-like domain. SND1 is a component of the RNA-induced silencing complex (RISC). This gene is highly conserved from yeast to human.
免疫原
peptide corresponding to the C-terminal region of human SND1 (GeneID: 27044), conjugated to KLH. The corresponding sequence is identical in mouse and rat.
应用
Anti-SND1 (C-terminal) antibody produced in rabbit has been used in immunoblotting, immunoprecipitation and immunofluorescence.
生化/生理作用
Staphylococcal nuclease and tudor domain containing 1 (SND1) has been shown to be involved in the regulation of transcription and RNA biogenesis. It is known to interact with nucleic acids and proteins. SND1 promotes the breakdown of hyper-edited inosine-containing miRNA precursors. It modulates miRNA transcription and translation through RNA editing by ADAR (adenosine deaminase acting on RNA). Increased SND1 expression is seen in human colon cancer tissues and cell lines.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing
Li CL, et al.
Nucleic Acids Research, 36(11), 3579-3589 (2008)
Naoto Tsuchiya et al.
Cancer research, 67(19), 9568-9576 (2007-10-03)
Colon cancers have been shown to develop after accumulation of multiple genetic and epigenetic alterations with changes in global gene expression profiles, contributing to the establishment of widely diverse phenotypes. Transcriptional and posttranscriptional regulation of gene expression by small RNA
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