Anti-RASD1

Ras-related dexamethasone-induced 1 (RASD1) belongs to the Ras family of monomeric G-proteins and was initially recognized as a dexamethasone inducible gene. RASD1 comprises an effector loop, four highly conserved guanosine-5′-triphosphate (GTP) binding and hydrolysis pockets (Σ1-Σ4). The Σ1 and Σ2 pockets have phosphate-magnesium binding domains and the Σ3 and Σ4 comprises guanine nucleotide binding loops. The C-terminal region of RASD1 includes a cationic CAAX-domain. RASD1 is expressed in the liver, heart, white adipose tissues and kidneys. The RASD1 gene is present at the human chromosome location 17p11.2.

synthetic peptide corresponding to an internal region of human RASD1, conjugated to KLH. The corresponding sequence is identical in mouse and rat RASD1.

Anti-RASD1 is suitable for use in immunoblotting.

Anti-RASD1 specifically recognizes human RASD1.

Ras-related dexamethasone-induced 1 (RASD1) /Dexras1 modulates various signaling pathways like, N-methyl-d-aspartic acid receptors (NMDAR)-nitric oxide, G-protein coupled receptors (GPCRs), mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) and protein kinase C (PKC). Dexras1 functions as a novel physiological target of neuronal NO synthase (nNOS). The development of a ternary complex between nNOS, the nNOS adaptor protein CAPON and DexRAS1 promotes the ability of nNOS to activate Dexras1. It is S-nitrosylated, which is activated by nitric oxide (NO) donors and by NMDA receptor-stimulated NO-synthesis in cortical neurons. Knock-out of nNOS in mice results in the selective reduction of Dexras1 activation. NMDA receptor-enhanced NO-signaling mediates neuronal iron homeostasis through Dexras1. An iron-uptake signaling cascade including NMDA-NO-Dexras1-peripheral benzodiazepine receptor associated protein (PAP7)-divalent metal transporter 1 (DMT1) facilitates NMDA neurotoxicity. Dexras1 interacts with FE65 and directly regulates FE65-amyloid precursor protein (APP)-mediated transcription.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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