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Merck
CN

SAB4200525

Sigma-Aldrich

Anti-Kindlin-2 antibody, Mouse monoclonal

clone 3A3, purified from hybridoma cell culture

别名:

Monoclonal Anti-KIND2, Monoclonal Anti-Kindlin-2 antibody produced in mouse, Monoclonal Anti-MIG2, Monoclonal Anti-Mitogen-inducible gene 2 protein, Monoclonal Anti-PH domain-containing family C member 1, Monoclonal Anti-PLEKHC1, Monoclonal Anti-UNC112, Monoclonal Anti-UNC112B, Monoclonal Anti-family C (with FERM domain) member 1, Monoclonal Anti-fermitin family member 2, Monoclonal Anti-mig-2, Monoclonal Anti-mitogen inducible gene 2 protein, Monoclonal Anti-pleckstrin homology domain containing

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UNSPSC代码:
12352203
NACRES:
NA.41

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生物来源

mouse

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

3A3, monoclonal

表单

buffered aqueous solution

分子量

antigen ~72 kDa

种属反应性

bovine, monkey, human, mouse, rat, dog

浓度

~1.0 mg/mL

技术

western blot: 1.0-2.0 μg/mL using HeLa total cell extracts

同位素/亚型

IgG1

UniProt登记号

Q96AC1

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... FERMT2(10979)
mouse ... Fermt2(218952)
rat ... Fermt2(289992)

一般描述

Monoclonal Anti-Kindlin-2 (mouse IgG1 isotype) is derived from the hybridoma 3A3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Kindlin-2 belongs to the Kindlin family of focal adhesion proteins. It is localized in all solid tissues of mesenchymal origin. Kindlin-2 consists of band 4.1 protein, ezrin, radixin and moesin (FERM) and pleckstrin homology (PH) domains. It is mapped on the human chromosome at 14q22.1.

免疫原

recombinant C-terminal region fusion protein of human Kindlin-2.1 The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

应用

Monoclonal Anti-Kindlin-2 antibody produced in mouse may be used in:
  • immunoblotting
  • flow cytometry
  • immunoprecipitation
  • immunocytochemistry
  • immunohistochemistry

生化/生理作用

Kindlin-2 plays an important role in integrin-mediated cell-extracellular matrix (ECM) adhesion and invasion. It is also involved in wound healing, angiogenesis and embryonic development. Deficiency of kindlin-2 leads to the lethality of embryos. Kindlin-2 expression can be altered by malignant transformations such as breast cancer and leiomyomas.
Monoclonal Anti-Kindlin-2 recognizes human, monkey, bovine, dog rat and mouse kindlin-2.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

制备说明

For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
019M4806V
112M4823V
112M4823

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Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus
Moretti F, et al.
eLife, 7(10), e35816-e35816 (2018)
Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins
Qu H, et al.
Journal of Cell Science, 124(6), 879-891 (2011)
Kindlin-2 controls bidirectional signaling of integrins
Montanez, et al.
Genes & Development, 22(10), 1325-1330 (2008)
Kindlin-2: a novel prognostic biomarker for patients with hepatocellular carcinoma
Ge Y, et al.
Pathology Research and Practice, 211(3), 198-202 (2015)
Kindlins in FERM adhesion
Malinin NL, et al.
Blood, 115(20), 4011-4017 (2010)
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