SAB4200624
Anti-EXOSC1 antibody, Mouse monoclonal
clone EX-1, purified from hybridoma cell culture
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UNSPSC Code:
12352203
Clone:
EX-1, monoclonal
Species reactivity:
mouse, human, rat
Application:
FACS
Citations:
3
biological source
mouse
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
EX-1, monoclonal
mol wt
~21 kDa
species reactivity
mouse, human, rat
concentration
~1.0 mg/mL
technique(s)
flow cytometry: 5-10 μg/test using HeLa cells, immunoblotting: 1-2 μg/mL using whole extracts of HEK 293 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EXOSC1(51013)
mouse ... Exosc1(66583)
rat ... Exosc1(679140)
General description
The exosome component 1 (EXOSC1) gene is located on human chromosome 10q24.1.
The gene EXOSC1 (exosome component 1) encodes one of the nine core subunits of the exosome complex. The protein is also referred to as Csl4 and has high affinity for RNA.
Biochem/physiol Actions
The exosome complex facilitates the splicing and degradation of mRNAs and non-coding RNAs. It is also essential for epigenetic gene regulation. It endogenously suppresses erythroid maturation. Within the complex, Exosc1 (exosome component 1) associates with Exosc6 to stabilize the complex. The binding of Exosc10 to Exosc1, Exosc6, and Exosc8 enhances the activity of the complex and positions Exosc1 for RNA binding.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
Other Notes
synthetic peptide corresponding to a sequence at the internal region of human EXOSC1 conjugated to KLH
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Eun Kyeong Oh et al.
International journal of oncology, 41(6), 2038-2046 (2012-10-02)
Host genomic alterations in addition to human papillomavirus (HPV) are needed for cervical precursor lesions to progress to invasive cancer because only a small
The RNA-Degrading Exosome Complex Is an Endogenous Suppressor of Erythroid Maturation.
McIver S
Blood, 124, 2659-2659 (2014)
Skye C McIver et al.
Blood, 124(14), 2285-2297 (2014-08-15)
Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. Previously, we described a role for the master regulator of erythropoiesis, GATA-1, in inducing genes encoding components of the autophagy machinery. In
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