产品名称
Anti-Copeptin antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunoblotting: 0.25-0.5 μg/mL (recommended using recombinant human Copeptin trifluoroacetate)
immunohistochemistry: 20 μg/mL (recommended using mouse or human kidney sections)
immunoprecipitation (IP): 5-10 μg (recommended using recombinant human Copeptin trifluoroacetate (C8749).)
indirect ELISA: 0.25-0.5 μg/mL (recommended using human Copeptin trifluoroacetate (C8749) for coating.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AVP(551)
Immunogen
a synthetic peptide corresponding to the C-terminal region of human Copeptin
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Application
Anti-Copeptin antibody produced in rabbit has been used in various immunochemical techniques including :
- immunohistochemistry
- immunoblotting
- immunoprecipitation
- enzyme linked immunosorbent assay (ELISA)
Biochem/physiol Actions
Copeptin concentration directly reflects AVP activation and serves as a biomarker of the AVP system. Altered copeptin levels are implicated in stroke, sudden death and cardiovascular events. It can also be used as a biomarker for a list of illnesses, such as acute myocardial infarction (AMI), vasodilatory shock, metabolic syndrome, diabetes insipidus, diabetes mellitus, sepsis, septic shock, lower respiratory tract infections, hyponatremia, acute dyspnea, autosomal dominant polycystic kidney disease (ADPKD), intracerebral hemorrhage, pulmonary arterial hypertension (PAH) and head injury.
The gene AVP (arginine vasopressin) encodes preprovasopressin which is processed into vasopressin, neurophysin II and glycoprotein (copeptin). Mutations in it are associated with neurohypophyseal diabetes insipidus. It also plays a crucial role in social mannerism, such as recognition, aggression, reproduction and parenting. The levels of circulating copeptin is higher in children suffering from febrile seizures.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
AVP or pre-proAVP, also known as, vasopressin-neurophysin 2-copeptin is one of the main hormones of the axis hypothalamic-pituitary adrenal. It is split into 3 chains: Arg-vasopressin, neurophysin-2 and copeptin. Copeptin is a glycopeptide with 39 amino acids, located at the C-terminal part of the pre-proAVP. It is secreted by the posterior pituitary gland and poured into the systemic circulation.
The gene AVP (arginine vasopressin) is mapped to human chromosome 20. It is an antidiurectic hormone which is produced by hypothalamic neurons.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Jia Jia Liu et al.
PloS one, 10(8), e0136436-e0136436 (2015-08-22)
Arginine vasopressin (AVP) plays a role in social behavior, through receptor AVPR1A. The promoter polymorphism AVPR1A RS3 has been associated with human social behaviors, and with acute response to stress. Here, the relationships between AVPR1A RS3, early-life stressors, and social
Copeptin and its potential role in diagnosis and prognosis of various diseases
Dobvsa L and Cullen EK
Biochemical Medicine, 23(2), 172-190 (2013)
Benjamin Stöcklin et al.
PloS one, 10(4), e0124663-e0124663 (2015-04-22)
Accurate diagnosis of febrile seizures in children presenting after paroxysmal episodes associated with fever, is hampered by the lack of objective postictal biomarkers. The aim of our study was to investigate whether FS are associated with increased levels of serum
Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension
Nickel NP, et al.
Respiratory Research, 14(1), 130-130 (2013)
U Bahnsen et al.
The EMBO journal, 11(1), 19-23 (1992-01-01)
Familial neurohypophyseal diabetes insipidus in humans is a rare disease transmitted as an autosomal dominant trait. Affected individuals have very low or undetectable levels of circulating vasopressin and suffer from polydipsia and polyuria. An obvious candidate gene for the disease
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