Anti-Burkholderia pyrrocinia (Pseudomonas pyrrocinia) antibody produced in rabbit

Burkholderia pyrrocinia (previously also known as Burkholderia Pseudomonas) ) belongs to the Burkholderia cepacia complex (Bcc). Burkholderia cepacia complex is a group of at least 20 gram negative bacterial species that are widely distributed in the natural environment such as, soil and water.1 These bacteria have unusually large genomes (7.5-8.5 Mb).2 B. cepacia are opportunistic and nosocomial pathogens that affect mostly immunocompromised individuals such as cystic fibrosis (CF) patients and cause respiratory illness and chronic inflammation.3First, the bacterium initiates primary infection in the respiratory mucosa followed by spreading to adjacent organs and establishing the “cepacia syndrome.

The antibody may be used in various immunochemical techniques including Immunoblotting. Detection of the Burkholderia pyrrocinia bands by Immunoblotting is specifically inhibited by the immunogen.

B. cepacia has the ability to survive intracellularly in alveolar phagocytes and respiratory epithelial cells.8 Moreover, B. cepacia produces quorum sensing (QS) molecules that control virulence factor expression and biofilm formation that shields the bacteria from immune response and antibiotic treatment.1 Bcc are resistant to various types of antibiotics such as, quinolones, aminoglycosides and ß-lactams.1

Anti-Burkholderia pyrrocinia antibody recognizes B. pyrrocinia lysate and whole dead bacteria.

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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