biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: 1:25-1:100, western blot: 1:200-1:1000
accession no.
NP_055469
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SDC3(9672)
General description
Syndecan 3 (SDC3) also known as neuronal syndecan (N-syndecan), belongs to the transmembrane heparan sulphate proteoglycan family. It is expressed predominantly in brain, and also in ovary, uterus, cartilage, skeletal muscle and pancreatic cells. In human chromosome, the gene SDC3 is localized on 1p35.2.
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human syndecan 3
Application
Anti-SDC3 has been used in western blot analysis and immunohistochemistry studies.
Biochem/physiol Actions
Syndecan 3 (SDC3) maintains cell shape and transfers signals from the cell surface to actin cytoskeleton. It depends on carbohydrate for the process. SDC3 is a potential modulator of gonadal steroid hormone function. SDC3 is a co-receptor for growth factors and extracellular matrix components like basic fibroblast growth factor, heparin binding growth-associated molecule, epidermal growth factor receptor and notch signalling ligands. Thus, SDC3 is involved in various functions like cell adhesion, cell-cell interaction and regulation of ligand-receptor binding. In brain, SDC3 regulates neurite outgrowth and neuronal migration. SDC3 is involved in formation of synapses to maintain homeostasis of feeding behaviour and body weight. SDC3 is one of the potential marker for obesity. Polymorphism is SDC3 leads to obesity and in female obesity is linked with hyperandrogenism. SDC3 binds with tissue factor pathway inhibitor (TFPI) in the cell surface of cancer cells. High expression of SDC3 and Pleiotrophin is involved in metastasis and tumor progression in pancreatic cancer. SDC3 expression is regulated by microRNA (miR-144-5p) (passenger strand) and leads to cancer cell aggressiveness in renal cancer.
Features and Benefits
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Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Yasutaka Yamada et al.
Cancer science, 109(9), 2919-2936 (2018-07-04)
In the human genome, miR-451a, miR-144-5p (passenger strand), and miR-144-3p (guide strand) reside in clustered microRNA (miRNA) sequences located within the 17q11.2 region. Low expression of these miRNAs is significantly associated with poor prognosis of patients with renal cell carcinoma
Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer
Yao J, et al.
World Journal of Gastroenterology, 23(21), 3907-3914 (2017)
Genes Implicated in Obesity and Overweight: Potential Biomarkers of Early Diagnosis
Gunturiz ML, et al.
Current Research in Clinical Diabetes and Obesity, 2018(1), 1-10 (2018)
The role of syndecans in the regulation of body weight and synaptic plasticity
Reizes O, et al.
The International Journal of Biochemistry & Cell Biology, 40(1), 28-45 (2008)
Andreas N Schüring et al.
Journal of molecular medicine (Berlin, Germany), 87(12), 1241-1250 (2009-10-13)
The heparan sulfate proteoglycan syndecan-3 (SDC3) is a novel regulator of feeding behavior and body weight. Recently, an association of SDC3 polymorphisms with obesity has been observed in Koreans. As female obesity is associated with hyperandrogenism and infertility, we studied
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