生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
rat, mouse, human
技术
immunohistochemistry: 1:25-1:100
western blot: 1:200-1:1000
登记号
NP_055469
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SDC3(9672)
一般描述
Syndecan 3 (SDC3) also known as neuronal syndecan (N-syndecan), belongs to the transmembrane heparan sulphate proteoglycan family. It is expressed predominantly in brain, and also in ovary, uterus, cartilage, skeletal muscle and pancreatic cells. In human chromosome, the gene SDC3 is localized on 1p35.2.
免疫原
Synthetic peptide corresponding to residues near the C terminal of human syndecan 3
应用
Anti-SDC3 has been used in western blot analysis and immunohistochemistry studies.
生化/生理作用
Syndecan 3 (SDC3) maintains cell shape and transfers signals from the cell surface to actin cytoskeleton. It depends on carbohydrate for the process. SDC3 is a potential modulator of gonadal steroid hormone function. SDC3 is a co-receptor for growth factors and extracellular matrix components like basic fibroblast growth factor, heparin binding growth-associated molecule, epidermal growth factor receptor and notch signalling ligands. Thus, SDC3 is involved in various functions like cell adhesion, cell-cell interaction and regulation of ligand-receptor binding. In brain, SDC3 regulates neurite outgrowth and neuronal migration. SDC3 is involved in formation of synapses to maintain homeostasis of feeding behaviour and body weight. SDC3 is one of the potential marker for obesity. Polymorphism is SDC3 leads to obesity and in female obesity is linked with hyperandrogenism. SDC3 binds with tissue factor pathway inhibitor (TFPI) in the cell surface of cancer cells. High expression of SDC3 and Pleiotrophin is involved in metastasis and tumor progression in pancreatic cancer. SDC3 expression is regulated by microRNA (miR-144-5p) (passenger strand) and leads to cancer cell aggressiveness in renal cancer.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Yasutaka Yamada et al.
Cancer science, 109(9), 2919-2936 (2018-07-04)
In the human genome, miR-451a, miR-144-5p (passenger strand), and miR-144-3p (guide strand) reside in clustered microRNA (miRNA) sequences located within the 17q11.2 region. Low expression of these miRNAs is significantly associated with poor prognosis of patients with renal cell carcinoma
Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer
Yao J, et al.
World Journal of Gastroenterology, 23(21), 3907-3914 (2017)
Genes Implicated in Obesity and Overweight: Potential Biomarkers of Early Diagnosis
Gunturiz ML, et al.
Current Research in Clinical Diabetes and Obesity, 2018(1), 1-10 (2018)
The role of syndecans in the regulation of body weight and synaptic plasticity
Reizes O, et al.
The International Journal of Biochemistry & Cell Biology, 40(1), 28-45 (2008)
Andreas N Schüring et al.
Journal of molecular medicine (Berlin, Germany), 87(12), 1241-1250 (2009-10-13)
The heparan sulfate proteoglycan syndecan-3 (SDC3) is a novel regulator of feeding behavior and body weight. Recently, an association of SDC3 polymorphisms with obesity has been observed in Koreans. As female obesity is associated with hyperandrogenism and infertility, we studied
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持