产品名称
抗 胶原 II 兔抗, affinity isolated antibody
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 141 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COL2A1(1280)
一般描述
抗 胶原 II 抗体检测内源性总胶原 II 蛋白水平。
II型胶原蛋白α1链（COL2A1）基因位于人染色体12q13.11–q13.12。COL2A1属于胶原蛋白超家族。该编码蛋白的特征在于三条相同的α链形成的同型三聚体。II型胶原蛋白是软骨的主要成分。
免疫原
制备了抗人 II 型胶原合成肽的抗血清。
免疫原范围： 101-150
免疫原范围： 101-150
生化/生理作用
II 型胶原蛋白α1 链 (COL2A1)突变，导致骨骼发育不良、身材矮小、感官缺陷等多种临床表现，统称为 II 型胶原蛋白病。COL2A1 在关节软骨中的功能是形成高度组织化的纤维，这对组织的机械性质至关重要。
特点和优势
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多。
外形
兔 IgG 溶于磷酸盐缓冲盐水（不含 Mg2+ 和 Ca2+），pH7.4，150mM NaCl，0.02％ 叠氮化钠和 50％ 甘油中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Yu Yao et al.
International journal of molecular medicine, 41(1), 173-183 (2017-11-09)
Surgery-obtained synovium specimens (SSSs) can provide a source of synovial mesenchymal stem cells (SMSCs) for experimental studies. However, these specimens contain diverse tissues, including the intima and subintima; therefore, these SMSCs are not entirely derived from the intima and their cell source
E Takahashi et al.
Human genetics, 86(1), 14-16 (1990-11-01)
A new mapping system, based on nonisotopic in situ hybridization combined with fluorescent staining of replicated prometaphase R-bands, is described. Replication of the bands is achieved by treatment of thymidine-synchronized cells with bromodeoxyuridine. The human COL2A1 gene was mapped to
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International journal of molecular sciences, 22(21) (2021-11-14)
The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for de novo cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo
E V Isaeva et al.
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The aim of the study was to compare type I collagen-based and methacryloyl gelatin-based (GelMA) hydrogels by their ability to form hyaline cartilage in animals after subcutaneous implantation of scaffolds. Chondrocytes were isolated from the costal cartilage of newborn rats
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Osteoarthritis (OA) is a chronic condition caused by cartilage degradation, and there are currently no effective methods for preventing the progression of this disease; gene therapy is a relatively novel method for treating arthritis. Decreased collagen type II (Col2) expression
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