产品名称
抗 胶原 II 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 141 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL2A1(1280)
Biochem/physiol Actions
II 型胶原蛋白α1 链 (COL2A1)突变，导致骨骼发育不良、身材矮小、感官缺陷等多种临床表现，统称为 II 型胶原蛋白病。COL2A1 在关节软骨中的功能是形成高度组织化的纤维，这对组织的机械性质至关重要。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
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General description
抗 胶原 II 抗体检测内源性总胶原 II 蛋白水平。
II型胶原蛋白α1链（COL2A1）基因位于人染色体12q13.11–q13.12。COL2A1属于胶原蛋白超家族。该编码蛋白的特征在于三条相同的α链形成的同型三聚体。II型胶原蛋白是软骨的主要成分。
Immunogen
制备了抗人 II 型胶原合成肽的抗血清。
免疫原范围： 101-150
免疫原范围： 101-150
Physical form
兔 IgG 溶于磷酸盐缓冲盐水（不含 Mg2+ 和 Ca2+），pH7.4，150mM NaCl，0.02％ 叠氮化钠和 50％ 甘油中。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Mouna Barat-Houari et al.
Human mutation, 37(1), 7-15 (2015-10-08)
Mutations in the COL2A1 gene cause a spectrum of rare autosomal-dominant conditions characterized by skeletal dysplasia, short stature, and sensorial defects. An early diagnosis is critical to providing relevant patient care and follow-up, and genetic counseling to affected families. There
E Takahashi et al.
Human genetics, 86(1), 14-16 (1990-11-01)
A new mapping system, based on nonisotopic in situ hybridization combined with fluorescent staining of replicated prometaphase R-bands, is described. Replication of the bands is achieved by treatment of thymidine-synchronized cells with bromodeoxyuridine. The human COL2A1 gene was mapped to
Yu Yao et al.
International journal of molecular medicine, 41(1), 173-183 (2017-11-09)
Surgery-obtained synovium specimens (SSSs) can provide a source of synovial mesenchymal stem cells (SMSCs) for experimental studies. However, these specimens contain diverse tissues, including the intima and subintima; therefore, these SMSCs are not entirely derived from the intima and their cell source
Elena V Isaeva et al.
International journal of molecular sciences, 23(5) (2022-03-11)
The aim of this study was to verify the applicability of high-concentration collagen-based bioink with MSC (ADSC) and decellularized ECM granules for the formation of cartilage tissue de novo after subcutaneous implantation of the scaffolds in rats. The printability of
Shiping Shi et al.
Experimental and therapeutic medicine, 24(2), 526-526 (2022-07-16)
Osteoarthritis (OA) is a chronic condition caused by cartilage degradation, and there are currently no effective methods for preventing the progression of this disease; gene therapy is a relatively novel method for treating arthritis. Decreased collagen type II (Col2) expression
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