SAB4501317
Anti-MYLIP antibody produced in rabbit
affinity isolated antibody
别名:
Inducible degrader of the low-density lipoprotein receptor, E3 ubiquitin-protein ligase MYLIP, MIR, Myosin regulatory light chain-interacting protein
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 49 kDa
种属反应性
human, mouse, rat
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MYLIP(29116)
一般描述
The MYLIP (myosin regulatory light chain interacting protein) gene is mapped to human chromosome 6p22.3. The encoded protein is an E3 ubiquitin ligase, expressed in all tissues including hippocampus and cerebellum. Anti-MYLIP antibody detects endogenous levels of total MYLIP protein.
免疫原
The antiserum was produced against synthesized peptide derived from human MYLIP.
Immunogen Range: 161-210
Immunogen Range: 161-210
应用
Anti-MYLIP antibody produced in rabbit has been used in western blot analysis.
生化/生理作用
MYLIP (myosin regulatory light chain interacting protein) controls the LDLR (low density lipoprotein receptor) activity and stability, which might change due to fluctuation in the intracellular cholesterol levels. Mylip is associated with brain development. It induces platelet-derived growth factor (PDGF) signaling in fibroblasts. Mylip is also called as inducible degrader of the LDL-R (Idol), as it leads to receptor degradation, especially in macrophages and liver. It might serve as a target for drug development in disease.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Short-term use of atorvastatin affects glucose homeostasis and suppresses the expression of LDL receptors in the pancreas of mice
Yu Q, et al.
Molecular Medicine Reports, 18(3), 2780-2788 (2018)
Mylip makes an Idol turn into regulation of LDL receptor
Lindholm D, et al.
Cellular and Molecular Life Sciences, 66(21), 3399-3402 (2009)
Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome
Liu S and Vaziri ND
Nephrology, Dialysis, and Transplantation, 29(3), 538-543 (2013)
Shuman Liu et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(3), 538-543 (2013-10-30)
Nephrotic syndrome (NS) leads to elevation of serum total and LDL cholesterol. This is largely due to impaired LDL clearance, which is caused by hepatic LDL receptor (LDLR) deficiency despite normal LDLR mRNA expression, pointing to a post-transcriptional process. The
RP1-13d10. 2 is a novel modulator of statin-induced changes in cholesterol
Mitchel K, et al.
Circulation: Genomic and Precision Medicine, 9(3), 223-230 (2016)
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