SAB4502333
Anti-PRKAB1 antibody produced in rabbit
affinity isolated antibody
别名:
5′-AMP-activated protein kinase subunit β-1, AMPK, AMPK subunit β-1, AMPKb, PRKAB1
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 30 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PRKAB1(5564)
一般描述
Anti-PRKAB1 Antibody detects endogenous levels of total PRKAB1 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human PRKAB1.
Immunogen Range: 10-59
Immunogen Range: 10-59
应用
Anti-PRKAB1, N-Terminal antibody produced in rabbit is suitable for indirect ELISA and western blot applications.
生化/生理作用
PRKAB1 (protein kinase, AMP-activated, β 1 non-catalytic subunit) is a non-catalytic, β subunit of AMP-activated protein kinase (AMPK). It acts as a metabolic sensor for AMP levels. It plays a key role in energy sensor during the response to energy demand and supply. It regulates cell metabolism. It increases the glycolytic flux by H202 which increase intracellular NADPH content. The activity of PRKAB1 is controlled by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Cuilan Li et al.
Molecular cancer, 13, 49-49 (2014-03-08)
AMP-activated protein kinase (AMPK) is a key energy sensor that is involved in regulating cell metabolism. Our previous study revealed that the subunits of the heterotimeric AMPK enzyme are diversely expressed during ovarian cancer progression. However, the impact of the
Jonathan S Oakhill et al.
Science (New York, N.Y.), 332(6036), 1433-1435 (2011-06-18)
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) regulates whole-body and cellular energy balance in response to energy demand and supply. AMPK is an αβγ heterotrimer activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK activation depends
Shi-Bei Wu et al.
Biochimica et biophysica acta, 1822(2), 233-247 (2011-10-18)
We report that the energy metabolism shifts to anaerobic glycolysis as an adaptive response to oxidative stress in the primary cultures of skin fibroblasts from patients with MERRF syndrome. In order to unravel the molecular mechanism involved in the alteration
D Stapleton et al.
FEBS letters, 409(3), 452-456 (1997-06-16)
The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma (38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that
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