SAB4504031
抗-磷酸IRF-3 (pSer396) 兔抗
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
rat, mouse, human
Citations:
8
Technique(s):
ELISA: 1:20000
western blot: 1:500-1:1000
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
抗-磷酸IRF-3 (pSer396) 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 47 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer396)
Quality Level
Gene Information
human ... IRF3(3661)
Application
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
Biochem/physiol Actions
激活的IRF3（干扰素调节因子3）可通过Toll样受体（TLR3/4）介导的信号转导途径影响I型干扰素的表达。IRF3可以抑制神经胶质瘤的侵袭、增殖和迁移。研究表明IRF3可能具有抑制肿瘤的特征。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
IRF3（干扰素调节因子3）是一种属于IRF家族的转录因子，可参与针对病毒和细菌的先天免疫应答.IRF3编码基因位于人类染色体19q13.33上。
Immunogen
靶向人IRF-3 Ser396的磷酸化位点周围衍生的合成肽所产生的抗血清。
免疫原范围：362-411
免疫原范围：362-411
Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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Journal of Cellular Physiology (2017)
Interferon regulatory factor 3 in adaptive immune responses.-Laure Ysebrant de Lendonck
Laure Ysebrant de Lendonck
Cellular and Molecular Life Sciences (2014)
Interferon regulatory factor 3 alters glioma inflammatory and invasive properties
Leonid Tarassishin
Journal of Neuro-Oncology, 113 (2013)
Joyshree Karmakar et al.
Frontiers in immunology, 12, 626110-626110 (2021-03-26)
TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied. We earlier reported, TLR4 is hypersialylated due to reduced membrane-bound neuraminidase
Gina Córdoba-David et al.
Frontiers in pharmacology, 13, 987979-987979 (2022-11-18)
The type I interferon (TI-IFN) pathway regulates innate immunity, inflammation, and apoptosis during infection. However, the contribution of the TI-IFN pathway or upstream signaling pathways to tubular injury in kidney disease is poorly understood. Upon observing evidence of activation of
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