SAB4700541
Anti-CD261, low endotoxin antibody, Mouse monoclonal
clone DR-4-02, purified immunoglobulin, buffered aqueous solution
别名:
Anti-DR4, Anti-TNFRSF10A, Anti-TRAIL-R1
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
DR-4-02, monoclonal
表单
buffered aqueous solution
种属反应性
human
浓度
1 mg/mL
技术
flow cytometry: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
杂质
≤1 EU/μg endotoxin (LAL test)
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... TNFRSF10A(8797)
相关类别
一般描述
The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
免疫原
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 3-5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Manami Semba et al.
International journal of molecular sciences, 23(13) (2022-07-10)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytotoxic cytokine that induces cancer cell death by binding to TRAIL receptors. Because of its selective cytotoxicity toward cancer cells, TRAIL therapeutics, such as recombinant TRAIL and agonistic antibodies targeting TRAIL receptors
Shu Yang et al.
Oncology letters, 11(6), 4167-4176 (2016-06-18)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in the majority of tumor cells, whilst sparing normal cells. However, the potential use of TRAIL in the treatment of cancer is limited by the inevitable emergence of drug resistance.
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