一般描述
凝血酶是止血过程中的最终凝血蛋白酶，可同时促进促凝血和抗凝血作用。凝血酶也称为凝血因子IIa。 它是一种丝氨酸内肽酶，可特异性地在精氨酸的羧基侧水解肽和酯键。 该酶可将纤维蛋白原转化为纤维蛋白。
应用
凝血酶可用于重组融合蛋白的位点特异性切割，以除去带有可接近的凝血酶识别位点的重组融合蛋白中的亲和标签。凝血酶已被用于评估法国冻干血浆的体外止血特性。†
外形
以溶于20mM MES，pH 6.0,500mM氯化胆碱的溶液中的形式提供
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships
W Bode
Protein Science (1992)
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
Scott Kaatz
American Journal of Hematology (2012)
Fibrinogen and fibrin structure and functions
M W Mosesson
Journal of Thrombosis and Haemostasis, 3 (2005)
Brian J Grindel et al.
ACS omega, 5(39), 25440-25455 (2020-10-13)
Directed evolution is a powerful tool for the selection of functional ligands from molecular libraries. Extracellular domains (ECDs) of cell surface receptors are common selection targets for therapeutic and imaging agent development. Unfortunately, these proteins are often post-translationally modified and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持