InChI key
RCIPRGNHNAEGHR-ZLHAWHIKSA-N
InChI
1S/C55H86N14O16/c1-3-30(2)13-10-8-6-4-5-7-9-11-14-32-24-47(77)62-36(25-43(57)73)50(80)63-34(20-21-42(56)72)55(85)69-22-12-15-41(69)54(84)67-35(23-31-16-18-33(71)19-17-31)49(79)64-38(27-45(59)75)51(81)65-39(28-46(60)76)52(82)68-40(29-70)53(83)66-37(26-44(58)74)48(78)61-32/h16-19,30,32,34-41,70-71H,3-15,20-29H2,1-2H3,(H2,56,72)(H2,57,73)(H2,58,74)(H2,59,75)(H2,60,76)(H,61,78)(H,62,77)(H,63,80)(H,64,79)(H,65,81)(H,66,83)(H,67,84)(H,68,82)/t30?,32?,34-,35+,36-,37-,38+,39+,40+,41-/m0/s1
biological source
Bacillus subtilis
assay
≥90%
form
powder
color
white to slightly brown, white to slightly yellow
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
General description
Chemical structure: peptide
Mycosubtilin is an antifungal lipopeptide, which is a member of the iturin family. It contains a cyclic heptapeptide of LDDLLDL, which is completed by a β-amino acid containing a long hydrophobic tail. It was first obtained from Bacillus subtilis by Walton and Woodruff. As a monomer, it is insoluble in water.
Biochem/physiol Actions
Mycosubtilin has antifungal and anti-yeast properties, but is ineffective against virus and bacteria. Its antifungal property is attributed to its capability of permeabilization of the plasma membrane. This happens because of aberration in the osmotic potential leading to the formation of ion-conducting pores in the cell membrane. It has strong hemolytic activity.
Packaging
5MG
Preparation Note
Store at 2 to 8 °C. (Keep container tightly closed in a dry and well-ventilated place. Light seniture. Storage class (TRGS 510) Non Combustible liquids.)
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Storage class (TRGS 510): Non Combustible Solids
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
M Genest et al.
European journal of biochemistry, 169(2), 389-398 (1987-12-01)
The conformation in solution of mycosubtilin, an antifungal lipopeptide [cyclo(L-Asn-D-Tyr-D-Asn-L-Gln-L-Pro-D-Asn-L-Ser-beta-amino acid)]has been probed by two-dimensional nuclear magnetic resonance and restrained energy minimization. Several structures have been proposed belonging to the same family with minor local variations related to different orientations
Marc Ongena et al.
Trends in microbiology, 16(3), 115-125 (2008-02-22)
In the context of biocontrol of plant diseases, the three families of Bacillus lipopeptides - surfactins, iturins and fengycins were at first mostly studied for their antagonistic activity for a wide range of potential phytopathogens, including bacteria, fungi and oomycetes.
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