SMB00295
Ruscogenin
≥98% (HPLC)
别名:
(1β,3β,25R)-Spirost-5-ene-1,3-diol
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关于此项目
经验公式（希尔记法）:
C27H42O4
化学文摘社编号:
分子量:
430.62
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
产品名称
Ruscogenin, ≥98% (HPLC)
InChI
1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
SMILES string
C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
InChI key
QMQIQBOGXYYATH-IDABPMKMSA-N
assay
≥98% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Quality Level
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Application
Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.
Biochem/physiol Actions
Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.
General description
Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Qi Sun et al.
International immunopharmacology, 12(1), 88-93 (2011-11-15)
Acute lung injury is still a significant clinical problem with a high mortality rate and there are few effective therapies in clinic. Here, we studied the inhibitory effect of ruscogenin, an anti-inflammatory and anti-thrombotic natural product, on lipopolysaccharide (LPS)-induced acute
Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling.
T I Bonner
Trends in pharmacological sciences, 13(2), 48-50 (1992-02-01)
C J O'Brien et al.
World journal of surgery, 16(2), 222-226 (1992-03-01)
This retrospective study examines the experience of the Sydney Melanoma Unit in the management of cervical lymph nodes among patients with cutaneous melanoma of the head and neck. From 1960 to 1990, 397 patients had neck dissections for cutaneous malignant
Ya-Lin Huang et al.
Journal of pharmacological sciences, 108(2), 198-205 (2008-10-24)
Ruscogenin (RUS), first isolated from Ruscus aculeatus, also a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities. Our previous studies suggested that ruscogenin remarkably inhibited adhesion of leukocytes
J Vermeiren et al.
Acta orthopaedica Belgica, 58(1), 88-90 (1992-01-01)
Partial and sometimes full-thickness rotator cuff tears can be managed by arthroscopic debridement and anterior acromioplasty. The recent literature on shoulder arthroscopy does not however mention any alternative operation techniques for this very common lesion. We present a case of
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