SMB00295
Ruscogenin
≥98% (HPLC)
别名:
(1β,3β,25R)-Spirost-5-ene-1,3-diol
质量水平
方案
≥98% (HPLC)
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
InChI
1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
QMQIQBOGXYYATH-IDABPMKMSA-N
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一般描述
Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.
应用
Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.
生化/生理作用
Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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