SMB00336
马兜铃酸B
≥97% (HPLC)
别名:
6-硝基菲(3,4-d)-1,3-二恶唑-5-羧酸, 马兜铃酸, 马兜铃酸II
方案
≥97% (HPLC)
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
OC(C1=C2C([N+]([O-])=O)=CC3=CC=CC=C3C2=C4OCOC4=C1)=O
InChI
1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
InChI key
MEEXETVZNQYRSP-UHFFFAOYSA-N
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一般描述
马兜铃酸B或称马兜铃酸II （AA-II）是马兜铃科植物叶、根和茎中含量最丰富的次级代谢产物之一。AA-II 结构类似于马兜铃酸I（AA-I)），唯一差别在于C8上的甲氧基。
应用
马兜铃酸B可用于测试其对贵腐霉菌（Botrytis cinerea）的真菌毒性作用。它也已用作参考标准品，用于通过高效液相色谱/电喷雾电离质谱（HPLC/ESI-MS）研究其对体内代谢的作用。
生化/生理作用
马兜铃酸B能够以剂量依赖性的方式通过HSF-PLA2对体外磷脂的水解进行抑制。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 Inhalation - Muta. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sivaprasad Attaluri et al.
Nucleic acids research, 38(1), 339-352 (2009-10-27)
Aristolochic acids I and II (AA-I, AA-II) are found in all Aristolochia species. Ingestion of these acids either in the form of herbal remedies or as contaminated wheat flour causes a dose-dependent chronic kidney failure characterized by renal tubulointerstitial fibrosis.
Alena Dedı Ková et al.
Chemical research in toxicology, 33(11), 2804-2818 (2020-09-08)
The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal diseases associated with upper urothelial cancer. Differences in the metabolic activation and detoxification
R Melo et al.
Letters in applied microbiology, 68(1), 48-55 (2018-10-17)
The fungitoxic effect of aristolochic acids I and II on mycelial growth and conidial germination of Botrytis cinerea was analysed. Aristolochic acid I had a higher effect on mycelial growth of B. cinerea than aristolochic acid II with IC50 value
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