SMB00336
马兜铃酸B
≥97% (HPLC)
别名:
6-硝基菲(3,4-d)-1,3-二恶唑-5-羧酸, 马兜铃酸, 马兜铃酸II
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关于此项目
经验公式（希尔记法）:
C16H9NO6
化学文摘社编号:
分子量:
311.25
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
SMILES string
OC(C1=C2C([N+]([O-])=O)=CC3=CC=CC=C3C2=C4OCOC4=C1)=O
InChI key
MEEXETVZNQYRSP-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
General description
马兜铃酸B或称马兜铃酸II （AA-II）是马兜铃科植物叶、根和茎中含量最丰富的次级代谢产物之一。AA-II 结构类似于马兜铃酸I（AA-I)），唯一差别在于C8上的甲氧基。
Application
马兜铃酸B可用于测试其对贵腐霉菌（Botrytis cinerea）的真菌毒性作用。它也已用作参考标准品，用于通过高效液相色谱/电喷雾电离质谱（HPLC/ESI-MS）研究其对体内代谢的作用。
Biochem/physiol Actions
马兜铃酸B能够以剂量依赖性的方式通过HSF-PLA2对体外磷脂的水解进行抑制。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 Inhalation - Muta. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
R Melo et al.
Letters in applied microbiology, 68(1), 48-55 (2018-10-17)
The fungitoxic effect of aristolochic acids I and II on mycelial growth and conidial germination of Botrytis cinerea was analysed. Aristolochic acid I had a higher effect on mycelial growth of B. cinerea than aristolochic acid II with IC50 value
Alena Dedı Ková et al.
Chemical research in toxicology, 33(11), 2804-2818 (2020-09-08)
The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal diseases associated with upper urothelial cancer. Differences in the metabolic activation and detoxification
Sivaprasad Attaluri et al.
Nucleic acids research, 38(1), 339-352 (2009-10-27)
Aristolochic acids I and II (AA-I, AA-II) are found in all Aristolochia species. Ingestion of these acids either in the form of herbal remedies or as contaminated wheat flour causes a dose-dependent chronic kidney failure characterized by renal tubulointerstitial fibrosis.
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