SMB00445
灵芝酸 A
≥98% (HPLC)
别名:
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-二羟基-4,4,10,13,14-五甲基-3,11-二氧-2,5,6,7,12,15,16,17-八氢-1H-环戊基a[a]菲烯-17-基]-2-甲基-4-氧庚酸, (7β,15α,25R);7,15-二羟基-3,11,23-三氧-8-烯-26-酸
质量水平
方案
≥98% (HPLC)
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
OC(C(C)CC(C[C@@H](C)[C@H]1C[C@H](O)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)C(C[C@@H]3O)C(C)(C)C(CC4)=O)=O)=O
InChI
1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21?,23+,28+,29-,30+/m1/s1
InChI key
DYOKDAQBNHPJFD-ZQEHRSJRSA-N
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一般描述
灵芝酸A(Ganoderic Acid A)或GAA是灵芝(Ganoderma lucidum)真菌中最丰富的三萜类物质之一。GAA的化学结构中有四个环，在支链上有一个双键和一个末端羧基。
应用
灵芝酸A已用于：
- 研究其对缺氧诱导大鼠心肌细胞(H9c2)损伤的保护作用
- 作为参考标准品，研究其对豇豆植物中花生芽坏死病毒(GBNV)的抑制和抗病毒作用
- 作为傅里叶变换红外(FT-IR)光谱技术的标准品，分析灵芝来源的次级代谢物
生化/生理作用
灵芝酸A(GAA)可改善高脂饲料(HFD)喂养小鼠的脂质代谢、肠道菌群组成和高脂血症。它在多项体外研究中被证明可作为抗癌药物，抑制乳腺癌、人肝细胞癌细胞和骨肉瘤的细胞增殖。灵芝酸A对脑卒中后抑郁(PSD)大鼠模型具有抗抑郁样行为、炎症和神经损伤的神经保护作用。还具有抗人免疫缺陷型病毒(HIV-1)活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yanhua Chang et al.
Phytotherapy research : PTR, 33(5), 1448-1456 (2019-03-07)
Effects of ganoderic acid A (GAA), a lanostane triterpene, on hypoxia-ischemia encephalopathy (HIE) remain unclear. We aimed to figure out the specific role of GAA in hypoxia-treated neural stem cells (NSCs) as well as the regulatory mechanisms. Primary rat NSCs
Xu Wang et al.
Molecular medicine reports, 16(4), 3894-3900 (2017-07-22)
Ganoderic acid A (GA‑A), a triterpenoid, has been demonstrated to suppress cell proliferation in various cancers, including breast cancer and osteosarcoma. However, its effect on human hepatocellular carcinoma (HCC) remains to be elucidated. The present study aimed to investigate the
Jiahua Jiang et al.
International journal of molecular medicine, 21(5), 577-584 (2008-04-22)
Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, GA-H), were identified in an oriental medicinal mushroom Ganoderma lucidum. In the present study we evaluated the effect of GA-A, GA-H and GA-F on highly invasive human breast
B Sangeetha et al.
International journal of biological macromolecules, 189, 618-634 (2021-08-27)
Bud blight disease caused by groundnut bud necrosis virus (GBNV) is a serious constraint in the cultivation of agricultural crops such as legumes, tomato, chilies, potato, cotton etc. Owing to the significant damage caused by GBNV, an attempt was made
Ling Zhang et al.
Neuropsychiatric disease and treatment, 17, 2671-2681 (2021-08-24)
Post-stroke depression (PSD) is a common complication after stroke. Ganoderic acid A (GAA), one of the main bioactive Ganoderma triterpenoids, exerts preventive and therapeutic effects in many diseases. However, the function of GAA in PSD has not been well studied.
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