SMB00505
Echinocystic acid
≥95%
别名:
3β,16α-dihydroxyolean-12-en-28-oic acid
方案
≥95%
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
InChI
1S/C30H48O4/c1-25(2)14-15-30(24(33)34)19(16-25)18-8-9-21-27(5)12-11-22(31)26(3,4)20(27)10-13-28(21,6)29(18,7)17-23(30)32/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20-,21+,22-,23+,27-,28+,29+,30+/m0/s1
InChI key
YKOPWPOFWMYZJZ-PRIAQAIDSA-N
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一般描述
Echinocystic acid (EA) is a natural triterpene acid derivative. Its dehydrogenation in the presence of selenium has been reported. It has been reported to induce programmed cell death in human HepG2 (human hepatocellular liver carcinoma cell line) cells and human promyelocytic leukemia cells (HL-60). Due to its anticancer action, it is widely used in herbal medicines. EA undergoes oxidation in the presence of chromic acid to afford lactone of 3:12:16-triketo-13-hydroxyoleananonic acid. EA has been reported to be present in the bark and leaves of Pithecellobium dulce.
Echinocystic acid is an active component of Codonopsis lanceolata, which is treated as food and herbal medicine in Asia. Itis also found in fruits of Gleditsia sinensis.
应用
Echinocystic acid (EA) may be used for the synthesis of isonorechinocystenedione, via oxidation in the presence of Kiliani′s reagent.
生化/生理作用
Echinocystic acid is known to possess anti inflammatory property and might be effective in treating cough and bronchitis. Echinocystic acid prevents Hepatitis C virus (HCV) infection by inhibiting viral entry.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NFkB and MAPK pathways
Joh EH, et al.
Biochemical Pharmacology, 84(3) (2012)
α-Glucosidase and α-amylase inhibitory activities of Pithecellobium dulce bark and leaves.
Katekhaye SD and Nagmoti DM.
Phytopharmacology, 4(1), 123-130 (2013)
Elucidation of the pharmacophore of echinocystic acid, a new lead for blocking HCV entry
Wang, H, et al.
European Journal of Medicinal Chemistry, 64(1) (2013)
Xuhui Tong et al.
Biochemical and biophysical research communications, 321(3), 539-546 (2004-09-11)
Echinocystic acid (EA), a natural triterpone enriched in various herbs, has been showed to have cytotoxic activity in some cancer cells, and is used for medicinal purpose in many Asian countries. In the present study, we found that EA could
Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia
Wu J, et al.
Fitoterapia, 81(1) (2010)
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