质量水平
方案
≥98%
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
[H][C@@]12C[C@@H](C3=COC=C3)C(C)=C1[C@]([C@H](CC(OC)=O)[C@](C(C=C[C@]45C)=O)(C)[C@@]4([H])[C@@]6([H])OC5=O)(C)[C@]6([H])O2
InChI
1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29)31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17,21-23H,10-11H2,1-5H3/t15-,16-,17-,21-,22+,23-,25-,26+,27-/m1/s1
InChI key
JZIQWNPPBKFOPT-LSYMHUITSA-N
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一般描述
印苦楝内酯是一种具有 α，β-不饱和酮系统和 δ-内酯环的柠檬苦素类四降三萜化合物。它通常从 印苦楝树 （Neem）中分离出来。
应用
印苦楝内酯已被用作抗癌剂，研究其对人膀胱癌细胞系（EJ和5637）增殖、迁移和侵袭的影响。它还被用作靶向RNF114和捕获PARP1抑制剂（PARPi）和PARylation依赖性DNA修复因子的治疗方法。
生化/生理作用
印苦楝内酯具有抗疟疾、抗菌和抗癌活性。它已被证明可诱导骨肉瘤细胞凋亡，并通过调节整合素 αvβ5 的表达来抑制这些细胞的细胞迁移。 在人肾癌细胞中，印苦楝内酯诱导细胞周期停滞、DNA损伤和凋亡。已经证明它调节胰腺癌中的自噬和凋亡。
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms.
Bodduluru L N, et al.
Toxicology in vitro, 28(5), 1026-1035 (2014)
S Rochanakij et al.
The Southeast Asian journal of tropical medicine and public health, 16(1), 66-72 (1985-03-01)
The terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit Plasmodium falciparum in culture with a moderate potency. The EC50 against the parasite line K1 from Thailand was approximately 2.0 microM (0.95 microgram/ml). The
Yi-Hsien Hsieh et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(10), 7539-7547 (2015-04-29)
Nimbolide is a tetranortriterpenoid isolated from the leaves and flowers of Azadirachta indica which has been shown to exhibit anticancer, antioxidant, anti-inflammatory, and anti-invasive properties in a variety of cancer cells. However, the anti-tumor effect on human renal cell carcinoma
Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors
Li Peng et al.,
bioRxiv : the preprint server for biology (2022)
Seung-Shick Shin et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 3753587-3753587 (2019-08-09)
Nimbolide, an active chemical constituent of Azadirachta indica, reportedly has several physiological effects. Here, we assessed novel anticancer effects of nimbolide against bladder cancer EJ and 5637 cells. Nimbolide treatment inhibited the proliferation of both bladder cancer cell lines with
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