重组
expressed in CHO cells
浓度
≥20 μg/mL (rCETP protein)
500-900 μg/mL (total protein)
储存温度
−70°C
一般描述
Cholesteryl ester transfer protein (CETP) is a hydrophobic glycoprotein. It is released mostly from the liver. CETP is present in normal human plasma. The CETP gene is mapped to human chromosome 16q13. It has 16 exons, that spans around 25 kb. The mature CETP consists of four N-linked sugars with a variable glycosylation site.
生化/生理作用
Cholesteryl ester transfer protein (CETP) transfers neutral lipids from high-density lipoproteins (HDL) to very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway. Recombinant CETP is partially purified from CHO cells overexpressing the full-length human protein. This recombinant protein is active, and is useful as a source of CETP for mass or activity assays, high-throughput screening, or for performing structure-activity relationship (SAR) studies on inhibitor compounds.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Inhalation
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Hiroshi Okamoto et al.
Clinica chimica acta; international journal of clinical chemistry, 375(1-2), 92-98 (2006-07-25)
Cholesteryl ester transfer protein (CETP) is suggested to be involved in the cholesterol level in remnant like lipoprotein particles (RLP), but there is no direct evidence that CETP increases cholesterol-rich RLP in plasma. Human plasma was incubated with or without
Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis
Barter P J, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 23(2), 160-167 (2003)
Gerard Vassiliou et al.
Journal of lipid research, 45(9), 1683-1693 (2004-07-03)
Previous reports attributed cholesteryl ester transfer protein (CETP)-mediated HDL cholesteryl ester (CE) selective uptake to the CETP-mediated transfer of CE from HDL to newly secreted apolipoprotein B-containing lipoproteins, which are then internalized by the LDL receptor (LDL-R). CETP has also
Hiroshi Deguchi et al.
Thrombosis and haemostasis, 98(6), 1160-1164 (2007-12-08)
Dyslipoproteinemia involving low levels of high density lipoprotein (HDL) is linked to venous thrombosis in young male adults and to recurrence of venous thrombosis in patients who have experienced a previous unprovoked venous thrombosis episode. Plasma cholesteryl ester transfer protein
Rita Tory et al.
International journal of pharmaceutics, 358(1-2), 219-223 (2008-05-02)
Cyclosporine A (CsA), Rapamycin (RAPA), Tacrolimus (FK-506) and Mycophenolate mofetil (MMF) are immunosuppressants that are widely used in solid organ transplant patients. However, some of these drugs have been reported to cause dyslipidemia in patients. Our aim was to determine
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