recombinant
expressed in CHO cells
concentration
≥20 μg/mL (rCETP protein), 500-900 μg/mL (total protein)
storage temp.
−70°C
General description
Cholesteryl ester transfer protein (CETP) is a hydrophobic glycoprotein. It is released mostly from the liver. CETP is present in normal human plasma. The CETP gene is mapped to human chromosome 16q13. It has 16 exons, that spans around 25 kb. The mature CETP consists of four N-linked sugars with a variable glycosylation site.
Biochem/physiol Actions
Cholesteryl ester transfer protein (CETP) transfers neutral lipids from high-density lipoproteins (HDL) to very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway. Recombinant CETP is partially purified from CHO cells overexpressing the full-length human protein. This recombinant protein is active, and is useful as a source of CETP for mass or activity assays, high-throughput screening, or for performing structure-activity relationship (SAR) studies on inhibitor compounds.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis
Barter P J, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 23(2), 160-167 (2003)
Hiroshi Okamoto et al.
Clinica chimica acta; international journal of clinical chemistry, 375(1-2), 92-98 (2006-07-25)
Cholesteryl ester transfer protein (CETP) is suggested to be involved in the cholesterol level in remnant like lipoprotein particles (RLP), but there is no direct evidence that CETP increases cholesterol-rich RLP in plasma. Human plasma was incubated with or without
Gerard Vassiliou et al.
Journal of lipid research, 45(9), 1683-1693 (2004-07-03)
Previous reports attributed cholesteryl ester transfer protein (CETP)-mediated HDL cholesteryl ester (CE) selective uptake to the CETP-mediated transfer of CE from HDL to newly secreted apolipoprotein B-containing lipoproteins, which are then internalized by the LDL receptor (LDL-R). CETP has also
Hiroshi Deguchi et al.
Thrombosis and haemostasis, 98(6), 1160-1164 (2007-12-08)
Dyslipoproteinemia involving low levels of high density lipoprotein (HDL) is linked to venous thrombosis in young male adults and to recurrence of venous thrombosis in patients who have experienced a previous unprovoked venous thrombosis episode. Plasma cholesteryl ester transfer protein
Saj Parathath et al.
The Journal of biological chemistry, 279(24), 24976-24985 (2004-04-03)
Scavenger receptor BI, SR-BI, is a physiologically relevant receptor for high density lipoprotein (HDL) that mediates the uptake of cholesteryl esters and delivers them to a metabolically active membrane pool where they are subsequently hydrolyzed. A previously characterized SR-BI mutant
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