SML0047
MoTP
≥98% (HPLC)
别名:
33N14, 4-(4-Morpholinobutylthio)phenol
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关于此项目
经验公式（希尔记法）:
C14H21NO2S
化学文摘社编号:
分子量:
267.39
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥80 mg/mL
储存温度
−20°C
SMILES字符串
Oc1ccc(SCCCCN2CCOCC2)cc1
InChI
1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2
InChI key
YHKNLUTUXZDOQI-UHFFFAOYSA-N
应用
MoTP may be used in cell signaling and differentiation studies.
生化/生理作用
Melanocytotoxic; reversibly blocks the specification of neural crest cells into melanocytes
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kleio Petratou et al.
PloS one, 16(1), e0244794-e0244794 (2021-01-14)
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neural, skeletogenic and pigment cell fates. Key transcription factors and extracellular signals
Li Liu et al.
Biomolecules, 10(9) (2020-09-24)
It has been reported that 5-hydroxytryptamine (5-HT) is related to melanogenesis in mice and melanoma cells. However, the underlying mechanisms of 5-HT in regulating pigmentation remains unknown. In this study, we aim to clarify the regulatory mechanism of 5-HT in
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