SML0049
水蓼二醛
≥97% (HPLC), Transient Receptor Potential Anykrin 1 channels activator, powder
别名:
(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
产品名称
水蓼二醛, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C[C@@H]1[C@@]2([C@H](C(CCC2)(C)C)CC=C1C=O)C
InChI
1S/C15H22O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,9-10,12-13H,4,6-8H2,1-3H3/t12-,13-,15+/m0/s1
InChI key
AZJUJOFIHHNCSV-KCQAQPDRSA-N
生化/生理作用
Polygodial is a TRPA1 activator; antifungal.
Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.
Polygodial is a sesquiterpene dialdehyde. It is obtained from the plants Polygonum hydropiper, Warburgia ugandensis, Pseudowintera colorata and Warburgia stuhlmannii. It exhibits antifeedant activity and antimicrobial activity against insects and microbes, respectively. It is responsible for the “hot taste” in peppery spices of traditional Japanese cuisine.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Isao Kubo et al.
Journal of agricultural and food chemistry, 53(5), 1818-1822 (2005-03-03)
The antifungal activity of ethylenediaminetetraacetic acid (EDTA) against Saccharomyces cerevisiae was significantly affected by various conditions such as inoculum size, pH, and metal ions (Mg(2+), Ca(2+)). EDTA was found to be effective against this yeast at the inoculum size of
Keiko Kuroiwa et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 44(8), 1236-1244 (2006-03-18)
A subchronic toxicity study of water pepper extract (WPE) from Polygonum hydropiper L. was conducted in groups of 10 male and 10 female F344 rats fed powdered diets containing 0, 62.5, 250, 1000 or 4000 ppm concentrations for 13 weeks.
Isao Kubo et al.
Phytotherapy research : PTR, 19(12), 1013-1017 (2005-12-24)
Polygodial was found to possess moderate antibacterial activity against gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus and gram-negative bacteria including Escherichia coli and Salmonella choleraesuis with minimum bactericidal concentrations (MBC) of 100 and 100 microg/mL (0.34 mm) and 100 and
Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae
Lunde CS and Kubo I
Antimicrobial Agents and Chemotherapy, 44(7), 1943-1953 (2000)
Daniela S Corrêa et al.
Parasitology research, 109(1), 231-236 (2011-01-19)
Parasitic protozoan diseases affect the poorest population in developing countries. Leishmaniasis and Chagas disease have been included among the most important threats for public health in Central and South American continent, with few therapeutic alternatives and highly toxic drugs. In
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