SML0201
SB 297006
≥98% (HPLC)
别名:
N-Benzoyl-4-nitro-L-phenylalanine ethyl ester
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关于此项目
经验公式（希尔记法）:
C18H18N2O5
化学文摘社编号:
分子量:
342.35
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
旋光性
[α]/D -60 to -78° in ethanol (c=1)
颜色
white to tan
溶解性
DMSO: ≥15 mg/mL
储存温度
2-8°C
SMILES字符串
CCOC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2ccccc2
InChI
1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1
InChI key
BEZXGSZPWXRHIN-INIZCTEOSA-N
应用
SB 297006 may be used to study CCR3-mediated cell signaling in asthma models.
生化/生理作用
CCR3 Antagonist
SB 297006 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.
SB-297006 is a potent, selective CCR-3 antagonist (IC50 = 60 nM). The compound blocked CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 210 nM; eotaxin-2, 90 nM and MCP4, 80 nM.
特点和优势
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Peter J Barnes
Annual review of pharmacology and toxicology, 42, 81-98 (2002-01-25)
Cytokines play a critical role in orchestrating and perpetuating inflammation in asthmatic airways and several specific cytokine and chemokine inhibitors are now in development for the treatment of asthma. Inhibition of IL-4 with soluble IL-4 receptors has shown promising early
Leyi Gong et al.
Expert opinion on therapeutic patents, 19(8), 1109-1132 (2009-07-30)
Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease. A patent literature review is presented of small molecule CCR3 antagonists comprising the
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