SML0223
唑来膦酸 一水合物
≥98% (HPLC), FPP synthase inhibitor, powder
别名:
P,P′-[1-羟基-2-（1H-咪唑-1-基）亚乙基]双膦酸 一水合物, [1-羟基-2-（1H-咪唑-1-基）乙烷-1,1-二基]双（膦酸） 一水合物, 唑来膦酸 一水合物
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关于此项目
经验公式（希尔记法）:
C5H10N2O7P2·H2O
化学文摘社编号:
分子量:
290.10
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
唑来膦酸 一水合物, ≥98% (HPLC)
SMILES string
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
InChI key
FUXFIVRTGHOMSO-UHFFFAOYSA-N
InChI
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to beige
solubility
H2O: ≥2 mg/mL
storage temp.
2-8°C
Quality Level
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相关类别
Application
唑来膦酸一水合物用作：
- 作为抑制剂，抑制胶质母细胞瘤、乳腺癌肿瘤细胞 和前列腺癌细胞系LAPC4的增殖
- 与 D,L-丙交酯75：乙交酯25（PLGA）形成缀合物，分析其在股骨远端的骨形成功能
- 作为胶质母细胞瘤细胞中法尼基二磷酸合酶的抑制剂
Biochem/physiol Actions
唑来膦酸（唑来膦酸盐）是一种双膦酸盐骨吸收抑制剂，是基焦磷酸（FPP）合成酶的抑制剂，其会导致破骨细胞活性的下游抑制并减少骨吸收和转换。它已被用于治疗绝经后的骨质疏松症，佩吉特病、高钙血症，并结合癌症化疗以治疗已经扩散到骨骼的癌症引起的骨损伤。
唑来膦酸（唑来膦酸盐）是一种骨吸收抑制剂，是基焦磷酸合成酶的抑制剂
Preparation Note
本品在溶液中极其不稳定，复溶后应尽快使用。如果一定要保存溶液，最多可在2-8ºC下存放24小时。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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