SML0227
JW74
≥98% (HPLC)
别名:
4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine, JW-74
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关于此项目
经验公式（希尔记法）:
C24H20N6O2S
化学文摘社编号:
分子量:
456.52
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
COc1ccc(cc1)-n2c(SCc3nc(no3)-c4ccc(C)cc4)nnc2-c5ccncc5
InChI
1S/C24H20N6O2S/c1-16-3-5-17(6-4-16)22-26-21(32-29-22)15-33-24-28-27-23(18-11-13-25-14-12-18)30(24)19-7-9-20(31-2)10-8-19/h3-14H,15H2,1-2H3
InChI key
KRIKILRRJCIWNB-UHFFFAOYSA-N
相关类别
应用
JW74 has also been used to test its efficacy in concurrent radiation and cisplatin (CDDP)-mediated cytotoxicity using HeLa and cervical carcinoma SiHa cell lines. It has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.
JW74 has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.
生化/生理作用
JW74 is a tankyrase inhibitor of β-catenin-mediated Wnt signaling activity. It degrades β-catenin by stabilizing axis inhibition protein (AXIN), a component of the β-catenin degradation complex. It reduces cell cycle progression and induces caspase-3 mediated cell apoptosis in osteosarcoma cells.
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW74 affects the multiprotein complex consisting of b-catenin/GSK-3b/AXIN/APC /CK1 that controls the degradation of b-catenin. JW74 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase. JW74 also inhibits tumor formation and growth in the small intestine and colon of ApcMin mice.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
The tankyrase-specific inhibitor JW 74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
Wessel Stratford E, et al.
Cancer medicine, 3(1), 36-46 (2014)
Yajun Luo et al.
The international journal of biochemistry & cell biology, 103, 125-134 (2018-08-25)
The dysregulation of long non-coding RNA (lncRNA) has increasingly been linked to human gastric cancer (GC). However, the LINC01606 expression level and clinical values, and its role in the molecular mechanism underlying GC remain largely unknown. In our research, we
Lorenzo M Fernandes et al.
Scientific reports, 8(1), 14268-14268 (2018-09-27)
Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with
Better Therapeutic Target to Enhance Cisplatin Sensitivity in Cervical Cancer: PARP-1 or beta-catenin
Mann M, et al.
Journal of Cancer Science & Therapy (4)
Wnt/beta-catenin signaling pathway activation is required for proliferation of chicken primordial germ cells in vitro
Lee H C, et al.
Scientific reports, 6, 34510-34510 (2016)
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