SML0258
CPPG
≥98% (HPLC)
别名:
(R,S)-α-Cyclopropyl-4-phosphonophenylglycine
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关于此项目
经验公式（希尔记法）:
C11H14NO5P
化学文摘社编号:
分子量:
271.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
SMILES string
NC(C1CC1)(C(O)=O)c2ccc(cc2)P(O)(O)=O
InChI key
IGODGTDUQSMDQU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: >5 mg/mL
storage temp.
room temp
Biochem/physiol Actions
(R,S)-α-Cyclopropyl-4-phosphonophenylglycine (CPPG) can be used in combination with scopolamine to treat the depressive disorder.
CPPG is a potent group II/III metabotropic glutamate receptor antagonist, with approximately 20-fold selectivity for mGlu group III over group II (IC50 values of 2.2 and 46.2 nM respectively).
CPPG is a potent group II/III metabotropic glutamate receptor antagonist.
Features and Benefits
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Mohaddeseh Ebrahimi-Ghiri et al.
Physiology & behavior, 224, 113034-113034 (2020-07-01)
Clinical trials have revealed that the muscarinic receptor antagonist scopolamine produces a fast and potent antidepressant response. However, the anticholinergic adverse effects and the risk of psychosis at higher doses limit the widespread clinical use of scopolamine. Combination therapy of
Emmanuel Dornier et al.
Nature communications, 8(1), 2255-2255 (2017-12-23)
The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that normal mammary epithelial cells consume glutamine, but do not
Kouji Fukuyama et al.
Biomolecules, 9(6) (2019-06-20)
Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamatergic pathway using
Gelareh Abulwerdi et al.
Neurochemistry international, 138, 104770-104770 (2020-05-27)
Chronic dysregulated microglial activation may lead to persistent inflammation and progressive neurodegeneration. A previous study reported that ADX88178, a putative metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM), exerts anti-inflammatory effects in microglia by activating mGluR4. We employed in
Xing Yang et al.
Frontiers in bioengineering and biotechnology, 8, 903-903 (2020-10-30)
A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and as its
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