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Merck
CN

SML0289

溴芬酸 钠

≥98% (HPLC), COX1 and COX2 inhibitor, powder

别名:

2-氨基-3-(4-溴苯甲酰基)苯乙酸 钠盐

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关于此项目

经验公式(希尔记法):
C15H11BrNNaO3
化学文摘社编号:
分子量:
356.15
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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产品名称

溴芬酸 钠, ≥98% (HPLC)

SMILES string

[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c2ccc(Br)cc2

InChI

1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;/h1-7H,8,17H2,(H,18,19);/q;+1/p-1

InChI key

HZFGMQJYAFHESD-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

faintly yellow to dark yellow

solubility

H2O: ≥5 mg/mL

storage temp.

2-8°C

Quality Level

Gene Information

Application

溴芬酸钠可用于:
  • 研究其与黑色素的结合能力
  • 合成溴芬酸吲哚二酮标准物
  • 分析其在猪结膜中的渗透性

Biochem/physiol Actions

溴芬酸展示解热和抑制前列腺素合成酶的特性。它对缓解术后白内障患者的眼痛和炎症有治疗作用。溴芬酸是对抗变应性结膜炎的有效药剂。它有望成为治疗急性肌肉疼痛、骨关节炎和类风湿性关节炎的良药。
溴芬酸是一种非甾体抗炎药(NSAID);COX1 和 COX2 抑制剂;眼科止痛药。
溴芬酸是一种非甾体类抗炎药(NSAID),可同时抑制 COX1 和 COX2。它用作眼科止痛药。

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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分析证书(COA)

Lot/Batch Number

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Keith A Warren et al.
Retina (Philadelphia, Pa.), 30(2), 260-266 (2010-02-23)
The purpose of this study was to evaluate the addition of topical nonsteroidal antiinflammatory drugs (NSAIDs) to intravitreal corticosteroid and antivascular endothelial growth factor injections for the treatment of chronic cystoid macular edema. Thirty-nine patients with chronic pseudophakic cystoid macular
Christina Flaxel et al.
Retina (Philadelphia, Pa.), 32(3), 417-423 (2011-08-25)
To evaluate whether bromfenac eyedrops and ranibizumab intravitreal injections would provide added efficacy over ranibizumab alone. This was a single-site, multiinvestigator, prospective, open-label, interventional, Phase II study of patients with new or recurrent exudative/neovascular age-related macular degeneration. Thirty eyes were
Ester Carreño et al.
Clinical ophthalmology (Auckland, N.Z.), 6, 637-644 (2012-05-10)
Ophthalmic bromfenac sodium sesquihydrate is a topically applied selective cyclooxygenase (COX)-2 inhibitor. It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo potency
Neal A Sher et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 25(2), 214-220 (2009-02-27)
To compare the efficacy of two topical nonsteroidal anti-inflammatory drugs with regards to the control of pain, burning, photophobia, foreign body sensation, and epithelial healing rates in patients who underwent photorefractive keratectomy (PRK). Two hundred twelve eyes were randomized to
Steven M Silverstein et al.
Current medical research and opinion, 27(9), 1693-1703 (2011-07-15)
To evaluate the efficacy and ocular safety of bromfenac ophthalmic solution 0.09% dosed once daily for the treatment of ocular inflammation and pain following cataract extraction with posterior chamber intraocular lens implantation. A total of 455 subjects (455 study eyes:

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