SML0318
Alvameline tartrate
≥97% (HPLC)
别名:
2-Ethyl-5-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-2H-tetrazole tartrate, 5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate, Lu 25-109; 3-(2-Ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methyl-pyridine tartrate
方案
≥97% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: >10 mg/mL
储存温度
2-8°C
SMILES字符串
O[C@@H]([C@H](O)C(O)=O)C(O)=O.CCn1nnc(n1)C2=CCCN(C)C2
InChI
1S/C9H15N5.C4H6O6/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8;5-1(3(7)8)2(6)4(9)10/h5H,3-4,6-7H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.0/s1
InChI key
JHGFYOXAUPXDGA-WUUYCOTASA-N
生化/生理作用
Alvameline (Lu 25-109) is a muscarinic M1 receptor agonist and M2/M3 receptor antagonist that was under investigation for the treatment of Alzheimer′s disease. Alvameline (Lu 25-109) improved cognitive function following traumatic brain injury (TBI) in rats, but failed to show significant positive results in clinical trials.
Alvameline is a muscarinic M1 receptor agonist.
特点和优势
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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