SML0318
Alvameline tartrate
≥97% (HPLC)
别名:
2-Ethyl-5-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-2H-tetrazole tartrate, 5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate, Lu 25-109; 3-(2-Ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methyl-pyridine tartrate
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经验公式（希尔记法）:
C9H15N5 · xC4H6O6
分子量:
193.25 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated
SMILES string
O[C@@H]([C@H](O)C(O)=O)C(O)=O.CCn1nnc(n1)C2=CCCN(C)C2
InChI
1S/C9H15N5.C4H6O6/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8;5-1(3(7)8)2(6)4(9)10/h5H,3-4,6-7H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.0/s1
InChI key
JHGFYOXAUPXDGA-WUUYCOTASA-N
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
Alvameline (Lu 25-109) is a muscarinic M1 receptor agonist and M2/M3 receptor antagonist that was under investigation for the treatment of Alzheimer′s disease. Alvameline (Lu 25-109) improved cognitive function following traumatic brain injury (TBI) in rats, but failed to show significant positive results in clinical trials.
Alvameline is a muscarinic M1 receptor agonist.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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