SML0380
FMP-API-1
≥98% (HPLC)
别名:
3,3′-Diamino-4,4′-dihydroxydiphenylmethane, 4,4′-Methylenebis(2-aminophenol), Bis(3-amino-4-hydroxyphenyl)methane
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选择尺寸
关于此项目
经验公式（希尔记法）:
C13H14N2O2
化学文摘社编号:
分子量:
230.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H14N2O2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7,16-17H,5,14-15H2
SMILES string
Nc1cc(Cc2ccc(O)c(N)c2)ccc1O
InChI key
KCFVSHSJPIVGCG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
FMP-API-1 is an inhibitor of AKAP-PKA interactions in vitro and in cultured cardiac myocytes that activates PKA. Apparently, FMP-API-1 binds to a novel allosteric regulatory site.
FMP-API-1 is an inhibitor of AKAP-PKA interactions.
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Air Sensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Fumiaki Ando et al.
Nature communications, 9(1), 1411-1411 (2018-04-14)
Congenital nephrogenic diabetes insipidus (NDI) is characterized by the inability of the kidney to concentrate urine. Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity. So
Louis-Philippe Bernier et al.
Cell reports, 27(10), 2895-2908 (2019-06-06)
Microglia, the brain's immune cells, maintain homeostasis and sense pathological changes by continuously surveying the parenchyma with highly motile large processes. Here, we demonstrate that microglia also use thin actin-dependent filopodia that allow fast nanoscale sensing within discrete regions. Filopodia
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