SML0440
Spautin-1
≥98% (HPLC), Autophagy inhibitor, powder
别名:
6-氟-N-[（4-氟苯基）甲基]-4-喹唑啉胺, C43
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关于此项目
经验公式（希尔记法）:
C15H11F2N3
CAS Number:
分子量:
271.26
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
Spautin-1, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
InChI
1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI key
AWIVHRPYFSSVOG-UHFFFAOYSA-N
应用
Spautin-1 已作为自噬抑制剂用于：
- 研究其对氧诱导视网膜病变小鼠模型中血管、神经胶质和神经元改变的影响
- 评估预处理对犬骨肉瘤细胞阿霉素反应的效果
- 在 Luminex 试验中研究其对氧化应激树突状细胞 (OS-DC) 产生白细胞介素 (IL)-6 的影响
生化/生理作用
Spautin-1 抑制两种泛素特异性肽酶 USP10 和 USP13 的活性，引起 III 类 PI3 激酶复合物的蛋白酶体降解增加，已被证明可调节自噬。
Spautin-1 是一种自噬抑制剂。
特异性强的自噬抑制剂-1（Spautin-1）是一种小分子，可以抑制自噬并诱导癌细胞死亡。它可通过降解 beclin-1 来抑制自噬。Spautin-1 可提高放射治疗和化学疗法在各种人类癌细胞系中的效率。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
Ge Yang et al.
Scientific reports, 7(1), 17970-17970 (2017-12-23)
Presenilin (PS1 or PS2) functions as the catalytic subunit of γ-secretase, which produces the toxic amyloid beta peptides in Alzheimer's disease (AD). The dependence of folding and structural stability of PSs on the lipophilic environment and mutation were investigated by
Kuntal Ganguly et al.
Drug delivery, 23(8), 2838-2851 (2015-11-05)
Microspheres of chitosan (CS) cross-linked with polyethylene glycol (PEG) were prepared by emulsion-cross-linking followed by the solvent evaporation technique. The formulations were characterized and subjected to in vitro and in vivo tests to assess cell growth, changes in cell morphology
Yanbin Ma et al.
PloS one, 8(2), e56500-e56500 (2013-02-26)
N-terminally his-tagged human mu opioid receptor, a G protein-coupled receptor was produced in E.coli employing synthetic codon-usage optimized constructs. The receptor was expressed in inclusion bodies and membrane-inserted in different E.coli strains. By optimizing the expression conditions the expression level
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