SML0440
Spautin-1
≥98% (HPLC), Autophagy inhibitor, powder
别名:
6-氟-N-[（4-氟苯基）甲基]-4-喹唑啉胺, C43
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关于此项目
经验公式（希尔记法）:
C15H11F2N3
化学文摘社编号:
分子量:
271.26
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Spautin-1, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
InChI
1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI key
AWIVHRPYFSSVOG-UHFFFAOYSA-N
应用
Spautin-1 已作为自噬抑制剂用于：
- 研究其对氧诱导视网膜病变小鼠模型中血管、神经胶质和神经元改变的影响
- 评估预处理对犬骨肉瘤细胞阿霉素反应的效果
- 在 Luminex 试验中研究其对氧化应激树突状细胞 (OS-DC) 产生白细胞介素 (IL)-6 的影响
生化/生理作用
Spautin-1 抑制两种泛素特异性肽酶 USP10 和 USP13 的活性，引起 III 类 PI3 激酶复合物的蛋白酶体降解增加，已被证明可调节自噬。
Spautin-1 是一种自噬抑制剂。
特异性强的自噬抑制剂-1（Spautin-1）是一种小分子，可以抑制自噬并诱导癌细胞死亡。它可通过降解 beclin-1 来抑制自噬。Spautin-1 可提高放射治疗和化学疗法在各种人类癌细胞系中的效率。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Leonhard H Urner et al.
Nature communications, 11(1), 564-564 (2020-01-30)
Detergents enable the purification of membrane proteins and are indispensable reagents in structural biology. Even though a large variety of detergents have been developed in the last century, the challenge remains to identify guidelines that allow fine-tuning of detergents for
Z Solhjou et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 17(9), 2326-2337 (2017-03-16)
Ischemia-reperfusion injury (IRI) evokes intragraft inflammatory responses, which markedly augment alloimmune responses against the graft. Understanding the mechanisms underlying these responses is fundamental to develop therapeutic regimens to prevent/ameliorate organ IRI. Here, we demonstrate that IRI results in a marked
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Kuntal Ganguly et al.
Drug delivery, 23(8), 2838-2851 (2015-11-05)
Microspheres of chitosan (CS) cross-linked with polyethylene glycol (PEG) were prepared by emulsion-cross-linking followed by the solvent evaporation technique. The formulations were characterized and subjected to in vitro and in vivo tests to assess cell growth, changes in cell morphology
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