SML0442
ML239
≥98% (HPLC)
别名:
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
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关于此项目
经验公式（希尔记法）:
C13H10Cl3N3O2
化学文摘社编号:
分子量:
346.60
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
SMILES string
Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1
InChI key
NVEDPFICKAIHKD-NGYBGAFCSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
Application
ML239 has been used as a proble in cellular lipid profiling.
Biochem/physiol Actions
ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.
ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC50 of 1.16 μM with 24-fold selectivity against the control cell line.
ML239 is an inhibitor of breast cancer stem cells.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Phenotypic High-Throughput Screening Elucidates Target Pathway in Breast Cancer Stem Cell-Like Cells
Carmody LC, et al.
Journal of Biomolecular Screening, 17(9), 1204-1210 (2012)
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Rees MG, et al.
Nature chemical biology, 12(2), 109-109 (2016)
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