SML0472
4-IPP
≥97% (HPLC)
别名:
4-碘-6-苯嘧啶
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关于此项目
经验公式（希尔记法）:
C10H7IN2
化学文摘社编号:
分子量:
282.08
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
SMILES string
Ic1cc(ncn1)-c2ccccc2
InChI key
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution, warmed)
storage temp.
−20°C
Quality Level
Application
在 体外 迁移测定中，4-IPP 已被用作条件培养基 (CM) 中的巨噬细胞的迁移抑制因子 (MIF)。
Biochem/physiol Actions
4- IPP是细胞渗透、有效的巨噬细胞迁移抑制因子（MIF）拮抗剂，共价修饰MIF的N末端脯氨酸。
4-IPP 是一种细胞渗透性、强效的巨噬细胞移动抑制因子 (MIF) 拮抗剂。
4-碘代-6-苯基嘧啶 (4-IPP) 有可能成为一种新的抗多倍体治疗剂，可在甲状腺癌患者中用于靶向多倍体肿瘤细胞。它可通过阻断IMF-κB途径抑制破骨细胞的生成。4-IPP 可作为巨噬细胞迁移抑制因子 (MIF) 的治疗靶点，用于治疗病理性溶骨性骨病和绝经后骨质流失。它可以阻止肺腺癌细胞的发育和运动，并可以刺激甲状腺癌的细胞凋亡和有丝分裂死亡。
存储类别
11 - Combustible Solids
wgk
WGK 3
Sarah Maria Johler et al.
Cancer immunology, immunotherapy : CII, 65(12), 1465-1476 (2016-09-16)
Macrophage migration inhibitory factor (MIF) is known to be involved in oncogenic transformation, tumour progression, and immunosuppression and is overexpressed in many solid tumours, including paediatric rhabdomyosarcoma (RMS). We investigated the function of MIF in RMS during treatment with cytotoxic
Yuxin Zhang et al.
Aging, 13(4), 5804-5823 (2021-02-19)
Joint capsule fibrosis caused by excessive inflammation leading to post-traumatic joint contracture (PTJC). Fibroblasts trigger inflammation under the challenge of various proinflammatory cytokines. Macrophage migration inhibitory factor (MIF) is a prominent proinflammatory cytokine involved in inflammation- and fibrosis-associated pathophysiology, we
Tali Lang et al.
Nature communications, 9(1), 2223-2223 (2018-06-10)
Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family cytokines. Here, we show
Nadège Kindt et al.
Journal of clinical medicine, 8(1) (2019-01-13)
Human papilloma virus (HPV) infection has been well-established as a risk factor in head and neck squamous cell carcinoma (HNSCC). The carcinogenic effect of HPV is mainly due to the E6 and E7 oncoproteins, which inhibit the functions of p53
Deepa Rajasekaran et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4961-4971 (2014-07-13)
We report a new inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC50 of 5.6 μg. We also find that D-DT and macrophage migration inhibitory
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