产品名称
CORM-3,
SMILES string
[Ru+2].[Cl-].NCC(=O)[O-].O=[C].O=[C].O=[C]
InChI key
BICHHHDSEZXKNN-UHFFFAOYSA-L
InChI
1S/C2H5NO2.3CO.ClH.Ru/c3-1-2(4)5;3*1-2;;/h1,3H2,(H,4,5);;;;1H;/q;;;;;+2/p-2
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
相关类别
Application
CORM-3（一氧化碳（CO）释放分子-3）已可用于研究其对巨噬细胞糖酵解所致NLRP3（含热蛋白结构域3富含亮氨酸重复序列的受体）炎性体激活以及高血糖症诱导的 IL-1β（白细胞介素-1 β）产生的影响。它还被用于研究其对原代兔晶状体上皮细胞中 H2O2诱导的细胞凋亡的保护作用。
Biochem/physiol Actions
CORM-3是一种水溶性一氧化碳释放分子。
CORM-3是一种水溶性一氧化碳（CO）释放分子，可用于研究CO对细胞系统的影响。最近研究发现，在血红素氧化酶催化的血红素降解过程中产生的一氧化碳（CO），是哺乳动物细胞中重要的气体信号传导介质。CORM-3已被证明具有抗炎和心脏保护作用。
CO具有抗凋亡功能，并且能够抗氧化损伤，促进内皮愈合。已知CORM-3对移植、心肌梗塞和类风湿性关节炎具有治疗效果。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages.
young S H, et al.
Biochemical and Biophysical Research Communications, 493(2), 957-963 (2017)
CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru (II) Dicarbonyl? Lysozyme Complex.
Santos-Silva T, et al.
Journal of the American Chemical Society, 133(5), 1192-1195 (2011)
Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)?induced oxidative stress and the activation of NF-?B signaling in lens epithelial cells.
Huang Y, et al.
Experimental Eye Research, 166, 29-39 (2018)
Eric K Patterson et al.
Experimental biology and medicine (Maywood, N.J.), 246(21), 2338-2345 (2021-07-23)
In sepsis-induced inflammation, polymorphonuclear neutrophils (PMNs) contribute to vascular dysfunction. The serine proteases proteinase 3 (PR3) and human leukocyte elastase (HLE) are abundant in PMNs and are released upon degranulation. While HLE's role in inflammation-induced endothelial dysfunction is well studied
Do Won Lee et al.
Biochemical and biophysical research communications, 493(2), 957-963 (2017-09-25)
Low dose of carbon monoxide (CO) has anti-inflammatory role through various signaling pathways. Cellular metabolism has been implicated in the activation of inflammation in immune cells. However, the mechanisms by which CO-dependent metabolic regulation affect the immune response remain unclear.
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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