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SML0521

ML 210

≥98% (HPLC), GPX4 inhibitor, powder

别名:

CID 49766530, ML-210, [4- [双（4-氯苯基）甲基] 哌嗪-1-基]-（5-甲基-4-硝基-1,2-恶唑-3-基）甲酮

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关于此项目

经验公式（希尔记法）:
C22H20Cl2N4O4
化学文摘社编号:
1360705-96-9
分子量:
475.32
UNSPSC Code:
12352200
PubChem Substance ID:
329825528
NACRES:
NA.77
MDL number:
MFCD22666407
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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产品名称

ML 210, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

storage temp.

2-8°C

SMILES string

Cc1onc(C(=O)N2CCN(CC2)C(c3ccc(Cl)cc3)c4ccc(Cl)cc4)c1[N+]([O-])=O

InChI

1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3

InChI key

VIBHJPDPEVVDTB-UHFFFAOYSA-N

Application

ML 210 可用作含硒酶谷胱甘肽过氧化物酶 4（GPX4）的抑制剂，以诱导癌细胞的铁死亡。此外，还可作为 GPX4 抑制剂研究 GPX4 的药理性抑制功能是否改变了粘附 MCF10A 和 Hs578t 细胞中 prominin2 表达并影响铁死亡。

Biochem/physiol Actions

ML 210 可作为含硒酶谷胱甘肽过氧化物酶 4（GPX4）的抑制剂。它对少数卵巢癌细胞系表现出细胞毒性。
在表达 RAS 癌基因的肿瘤细胞中，ML 210 诱导非凋亡性细胞死亡。
在表达 RAS 的肿瘤细胞中，ML 210 诱导细胞死亡。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000455990
0000455987
0000455987
0000455990
0000382063

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Amrita Basu et al.
Cell, 154(5), 1151-1161 (2013-09-03)
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) profiling to identify additional biomarkers of small-molecule sensitivities. We have quantitatively measured the sensitivity
Jianling Bi et al.
Cell death & disease, 10(10), 682-682 (2019-09-19)
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death driven by lipid hydroperoxides within biological membranes. Although therapy-resistant mesenchymal-high cancers are particularly vulnerable to ferroptosis inducers, especially phospholipid glutathione peroxidase 4 (GPx4) inhibitors, the underlying mechanism is yet to
Yilong Zou et al.
Nature, 585(7826), 603-608 (2020-09-18)
Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions2-5. However
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全球贸易项目编号

货号GTIN
SML0521-5MG04061832925752
SML0521-25MG04061832925745