Name: 葫芦素 E
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₃₂H₄₄O₈

CAS Number:

18444-66-1

分子量:

556.69

UNSPSC代码:

12352200

NACRES:

NA.77

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质量水平

100

方案

≥95% (HPLC)

表单

powder

旋光性

[α]/D -60 to -75°, c = 0.7 (CDCl₃)

颜色

white to beige

溶解性

DMSO: 15 mg/mL, clear

储存温度

−20°C

InChI

1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1

InChI key

NDYMQXYDSVBNLL-MUYMLXPFSA-N

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应用

Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.

生化/生理作用

Cucurbitacin E is a potent inhibitor of actin depolymerization.

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.