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Merck
CN

SML0602

Sigma-Aldrich

Propiverine hydrochloride

≥98% (HPLC)

别名:

α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester, α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride, (1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride, 1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

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关于此项目

经验公式（希尔记法）:
C23H29NO3 · HCl
化学文摘社编号:
54556-98-8
分子量:
403.94
UNSPSC代码:
12352200
NACRES:
NA.77

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方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

[Cl-].[N+H]1(CCC(CC1)OC(=O)C(OCCC)(c3ccccc3)c2ccccc2)C

InChI

1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H

InChI key

KFUJMHHNLGCTIJ-UHFFFAOYSA-N

一般描述

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

生化/生理作用

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence.

特点和优势

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

CorrosionExclamation mark
GHS05,GHS07

警示用语：

Danger

危险声明

H315,H318,H335

危险分类

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000209594
0000209594
0000194807
0000114362
0000112217

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Meihua Huang et al.
Arzneimittel-Forschung, 61(9), 494-501 (2011-10-28)
A rapid, sensitive and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the determination of propiverine hydrochloride (CAS 54556-98-8) in human plasma using cetirizine di-hydrochloride as internal standard (IS, CAS 8388-51-0). Following liquid-liquid extraction
Kate McKeage
Clinical drug investigation, 33(1), 71-91 (2013-01-05)
Propiverine is a well established antimuscarinic agent with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). As well as blocking muscarinic receptors in the detrusor muscle, the drug also inhibits cellular calcium influx
Momokazu Gotoh et al.
Urology, 78(4), 768-773 (2011-08-23)
To assess the responsiveness and minimal clinically important change (MCIC) in the Overactive Bladder Symptom Score (OABSS), a single score used to quantify overactive bladder symptoms. The data were derived from a clinical trial of propiverine in patients with overactive
Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic)
Madersbacher H, et al.
World Journal of Urology, 19(5), 324-335 (2001)
Saori Nishijima et al.
Life sciences, 89(13-14), 456-459 (2011-08-09)
We examined the influence of propiverine hydrochloride, an anticholinergic agent, on the micturition reflex, blood pressure, and plasma catecholamine levels in young rats and old rats. Male F344/DuCrlCrlj Fischer rats (young rats aged 2 months and old rats aged 26
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Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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