SML0631
NE-100
≥98% (HPLC)
别名:
4-Methoxy-3-(2-phenylethoxy)-N,N-dipropyl-benzeneethanamine hydrochloride, N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C21H29NO2.ClH/c1-4-22(5-2)15-13-19-11-12-20(23-3)21(17-19)24-16-14-18-9-7-6-8-10-18;/h6-12,17H,4-5,13-16H2,1-3H3;1H
InChI key
LPMIMPZUXJWRJJ-UHFFFAOYSA-N
Biochem/physiol Actions
NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors.
NE-100 is a potent and selective σ1 receptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Takahito Yamamoto et al.
Current drug metabolism, 7(2), 135-146 (2006-02-14)
The purpose of this study was to propose a new method to predict in vivo drug-drug interactions (DDIs) for a high clearance drug from in vitro data. As the high clearance drug, NE-100 (N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride) was used. First, approach
Yoko Hirata et al.
Journal of neurochemistry, 119(4), 839-847 (2011-09-03)
Chloroquine, a widely used anti-malarial and anti-rheumatoid agent, has been reported to induce apoptotic and non-apoptotic cell death. Accumulating evidence now suggests that chloroquine can sensitize cancer cells to cell death and augment chemotherapy-induced apoptosis by inhibiting autophagy. However, chloroquine
Claudio Bucolo et al.
European journal of pharmacology, 536(1-2), 200-203 (2006-04-04)
The effects of a novel N-methyladamantan-1-amine derivative [(-)-MR22] with high sigma1 receptor affinity were investigated on retinal degeneration using a rat model of ischemia-reperfusion injury. The animals were anaesthetized and retinal ischemia was induced by elevating the intraocular pressure to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0631-5MG | 04061832560052 |
| SML0631-25MG | 04061832560045 |