SML0631
NE-100
≥98% (HPLC)
别名:
4-Methoxy-3-(2-phenylethoxy)-N,N-dipropyl-benzeneethanamine hydrochloride, N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
储存温度
2-8°C
InChI
1S/C21H29NO2.ClH/c1-4-22(5-2)15-13-19-11-12-20(23-3)21(17-19)24-16-14-18-9-7-6-8-10-18;/h6-12,17H,4-5,13-16H2,1-3H3;1H
InChI key
LPMIMPZUXJWRJJ-UHFFFAOYSA-N
生化/生理作用
NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors.
NE-100 is a potent and selective σ1 receptor antagonist.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
José Manuel Entrena et al.
Pain, 143(3), 252-261 (2009-04-21)
We evaluated the role of sigma(1) receptors on capsaicin-induced mechanical hypersensitivity and on nociceptive pain induced by punctate mechanical stimuli, using wild-type and sigma(1) receptor knockout (sigma(1)-KO) mice and selective sigma(1) receptor-acting drugs. Mutation in sigma(1)-KO mice was confirmed by
Tamaki Ishima et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(7), 1656-1659 (2008-07-24)
In addition to acetylcholinesterase (AChE) inhibition, donepezil binds to sigma-1 receptors. In this study, we examined the effects of donepezil on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil significantly potentiated the NGF-induced neurite outgrowth in a concentration-dependent
Md Shenuarin Bhuiyan et al.
Expert opinion on therapeutic targets, 14(10), 1009-1022 (2010-08-21)
We here investigated the effect of sigma-1 receptor (Sig-1R) stimulation with fluvoxamine on myocardial hypertrophy, cardiac functional recovery and defined mechanisms underlying its cardioprotective action. Wistar rats subjected to bilateral ovariectomy (OVX) were treated with abdominal aortic banding between the
Takahito Yamamoto et al.
Current drug metabolism, 7(2), 135-146 (2006-02-14)
The purpose of this study was to propose a new method to predict in vivo drug-drug interactions (DDIs) for a high clearance drug from in vitro data. As the high clearance drug, NE-100 (N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride) was used. First, approach
Yoko Hirata et al.
Journal of neurochemistry, 119(4), 839-847 (2011-09-03)
Chloroquine, a widely used anti-malarial and anti-rheumatoid agent, has been reported to induce apoptotic and non-apoptotic cell death. Accumulating evidence now suggests that chloroquine can sensitize cancer cells to cell death and augment chemotherapy-induced apoptosis by inhibiting autophagy. However, chloroquine
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