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Merck
CN

SML0656

Sigma-Aldrich

洛克米兰酰胺

≥96% (HPLC), anti-cancer agent, film

别名:

(1R,2R,3S,3aR,8bS)-2,3,3a,8b-四氢-1,8b-二羟基-6,8-二甲氧基-3a-(4-甲氧基苯基)-N,N-二甲基-3-苯基-1H-环戊[b]苯并呋喃-2-羧酰胺, NSC 326408, Roc-A, 洛克米兰酰胺A

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关于此项目

经验公式（希尔记法）:
C29H31NO7
化学文摘社编号:
84573-16-0
分子量:
505.56
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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产品名称

洛克米兰酰胺, ≥96% (HPLC)

质量水平

100

方案

≥96% (HPLC)

表单

film

颜色

colorless

运输

wet ice

储存温度

−20°C

SMILES字符串

N(C)(C)C(=O)[C@H]1[C@H]([C@@]2([C@@](Oc5c2c(cc(c5)OC)OC)([C@@H]1c4ccccc4)c3ccc(cc3)OC)O)O

InChI

1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1

InChI key

DAPAQENNNINUPW-IDAMAFBJSA-N

相关类别

一般描述

已知楝酰胺来自于四氢苯并呋喃，并且也是树兰属植物的一种活性化合物。

应用

楝酰胺已被用作抗癌药用于治疗肠病毒71型神经发病机制并对抑制素的作用进行了研究。

生化/生理作用

楝酰胺与成骨细胞分化相关。在类风湿关节炎中，楝酰胺可能通过阻止参与其中的细胞因子的表达而抑制炎症。
楝酰胺是一种从树兰属中分离的有效抗癌剂。楝酰胺可抑制蛋白的合成而不影响DNA或RNA合成。最近的研究表明，楝酰胺可与禁止素（PHB）1和2结合，阻止PHB与CRaf之间的相互作用并抑制CRaf的活化，进而抑制CRaf-MEK-ERK信号转导。此外，楝酰胺也是一种抑制NF-κB和NF-AT活化的免疫抑制剂。
楝酰胺是一种有效的抗癌剂。

特点和优势

《受体分类和信号转导》手册的 MAPKKK 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000383537
0000383537
0000189946
0000189946
0000139551

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Peter Proksch et al.
Journal of immunology (Baltimore, Md. : 1950), 174(11), 7075-7084 (2005-05-21)
Aglaia (family Meliaceae) plants are used in traditional medicine (e.g., in Vietnam) for the treatment of inflammatory skin diseases and allergic inflammatory disorders such as asthma. Inflammatory diseases arise from inappropriate activation of the immune system, leading to abnormal expression
Gerhard Bringmann et al.
Journal of natural products, 66(1), 80-85 (2003-01-25)
Two rocaglamide-related natural products, the previously known compound 6-demethoxy-10-hydroxy-11-methoxy-6,7-methylendioxyrocaglamide (3), and cyclorocaglamide (4), its 8b,10-anhydro analogue, have been isolated from the tropical plant Aglaia oligophylla. Compound 4 is the first bridged cyclopentatetrahydrobenzofuran natural product, and it exhibited a CD spectrum
Chaidir et al.
Journal of natural products, 64(9), 1216-1220 (2001-09-29)
A phytochemical analysis of the leaves of Aglaia dasyclada collected in Yunnan Province (People's Republic of China) yielded five cyclopentabenzofurans (1-5) of the rocaglamide family that are common secondary metabolites of Aglaia species as well as four biogenetically related compounds
Angela A Salim et al.
Bioorganic & medicinal chemistry letters, 17(1), 109-112 (2006-10-24)
Two new compounds, a cyclopenta[bc]benzopyran, ponapensin (1), and an aglaialactone, 5,6-desmethylenedioxy-5-methoxy-aglalactone (2), together with nine known compounds were isolated from the CHCl(3) soluble extract of the leaves and twigs of Aglaia ponapensis. Their structures were established by spectroscopic data interpretation.
Parinuch Chumkaew et al.
Chemical & pharmaceutical bulletin, 54(9), 1344-1346 (2006-09-02)
Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3'-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3'-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures
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