SML0739
TAPI-1 acetate salt
≥97% (HPLC)
别名:
N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-Alaninamide acetate salt
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
运输
wet ice
储存温度
−20°C
SMILES字符串
N(O)C(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cc2c(cc1)cccc2)C(=O)N[C@@H](C)C(=O)NCCN
InChI
1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1
InChI key
AWNBSWDIOCXWJW-WTOYTKOKSA-N
相关类别
应用
TAPI-1 acetate salt has been used as a tumor necrosis factor(TNF)-α convertase/ADAM17/α-secretase (TACE) inhibitor.
生化/生理作用
TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).
TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-KB-dependent manner.
Shi Z, et al.
FEBS Journal, 284(7), 1096-1109 (2017)
Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
Kahr W H A, et al.
Nature Communications, 8, 14816-14816 (2017)
Vincent Lin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(43), 15329-15339 (2011-10-28)
The capacity of adult mammals to regenerate sensory hair cells is not well defined. To explore early steps in this process, we examined reactivation of a transiently expressed developmental gene, Atoh1, in adult mouse utricles after neomycin-induced hair cell death
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
Stefan Düsterhöft et al.
Cellular and molecular life sciences : CMLS, 78(11), 5015-5040 (2021-05-06)
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional
Laura M Breshears et al.
The Journal of biological chemistry, 287(39), 32578-32587 (2012-07-27)
Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS). SAgs deregulate the host immune system after penetrating epithelial barriers such as the vaginal mucosa. In response to TSST-1, human vaginal
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