SML0932
补骨脂定
≥98% (HPLC)
别名:
3,9-二羟基-2-异戊二烯, 3,9-二羟基-2-（3-甲基-2-丁烯基）-6H-苯并呋喃[3,2-c] [1]苯并吡喃-6-酮
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H16O5
化学文摘社编号:
分子量:
336.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3
SMILES string
CC(C)=CCC1=C(C=C(OC2=O)C(C(OC3=C4)=C2C3=CC=C4O)=C1)O
InChI key
YABIJLLNNFURIJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
正在寻找类似产品? 访问 产品对比指南
相关类别
Biochem/physiol Actions
补骨脂定是一种从补骨脂中提取的 Coumestan 衍生物。它能通过抑制环氧酶-2（COX-2）和5-脂氧合酶（5-LOX）表达表现出抗炎特性。除了抗癌和抗炎效果之外，补骨脂定还具有抗氧化、抗菌和抗抑郁作用。补骨脂定参与胰岛素信号的调控。它是用于治疗出血、遗尿、尿频、白癜风和牛皮癣等传统药物的主要成分。
补骨脂素是一种呋喃香豆素的天然产物，其已用于中药。 补骨脂素是一种PTP1B抑制剂，已被证明具有多种抗癌活性。补骨脂素在不依赖雄激素的前列腺癌细胞中可诱导ROS生成，从而导致细胞增殖受到抑制。研究已经发现补骨脂素可下调NOTCH1信号转导，并导致乳腺癌干细胞和乳腺癌细胞中的生长停滞。
补骨脂素是一种呋喃香豆素的天然产物，具有抗癌活性； PTP1B抑制剂。
Features and Benefits
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hee Jung Yang et al.
Biochemical pharmacology, 82(5), 524-534 (2011-06-15)
Radiotherapy is the most significant non-surgical cure for the elimination of tumor, however it is restricted by two major problems: radioresistance and normal tissue damage. Efficiency improvement on radiotherapy is demanded to achieve cancer treatment. We focused on radiation-induced normal
Li-Tao Yi et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(2), 510-519 (2007-11-17)
The antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia were investigated in the forced swimming test (FST) in ICR strain of male mice. Psoralidin significantly decreased immobility time and increased swimming behavior without altering climbing behavior in
Pallab Pahari et al.
The Journal of organic chemistry, 74(7), 2750-2754 (2009-03-04)
A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and
Luhua Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 67-74 (2005-05-21)
High-performance liquid chromatography (HPLC) was developed for fingerprint analysis of Psoralea corylifolia. Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn) technique was first employed to identify the components of the fingerprint. The samples were separated with an Alltima C18 column (250 mm
Raj Kumar et al.
Molecular cancer therapeutics, 9(9), 2488-2496 (2010-08-26)
Epidermal growth factor receptor (EGFR) activation is an important event that regulates mitogenic signaling, such as the Raf, mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 cascades. EGFR activation has been implicated in the transition of prostate cancer from
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持