Merck
CN

SML1072

Sigma-Aldrich

GSK-LSD1

≥98% (HPLC)

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别名:
GSK-LSD1(反式外消旋) 二盐酸盐, rel-N-[(1R,2S)-2-苯基环丙基] -4-哌啶胺盐酸盐(1:2)
Empirical Formula (Hill Notation):
C14H20N2 · 2HCl
分子量:
289.24
PubChem化学物质编号:

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

储存温度

2-8°C

SMILES string

C1(N[C@@H]2C[C@H]2C3=CC=CC=C3)CCNCC1

InChI

1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1

InChI key

BASFYRLYJAZPPL-UONOGXRCSA-N

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GSK-LSD1 ≥98% (HPLC)

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SML1072

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OG-L002 hydrochloride ≥98% (HPLC)

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SML1383

OG-L002 hydrochloride

MS049 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1553

MS049 盐酸盐

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

, light yellow to dark orange

color

white to beige

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 25 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

应用

GSK-LSD1已用作小鼠中的赖氨酸特异性脱甲基酶 1(LSD1)抑制剂,用于研究败血症诱导的死亡率。它还被用作抑制剂,用于研究苯乙肼激活人类免疫缺陷病毒(HIV)潜伏期是否由 LSD1 引起。

生化/生理作用

GSK-LSD1 是赖氨酸特异性脱甲基酶 1(LSD1)的有效选择性抑制剂。GSK-LSD1 通过改变基因表达模式有效抑制不同癌细胞系的增殖。有关完整特征描述的详细信息,请访问 Structural Genomics Consortium(SGC)网站上的 GSK-LSD1 探针目录

要了解用于表观遗传目标的其他 SGC 化学探针,请访问 sigma.com/sgc

特点和优势

GSK-LSD1 是一种表观遗传化学探针,是与 Structural Genomics Consortium (SGC) 合作研发的。想要了解更多信息并查看其他SGC表观遗传探针,请访问sigma.com/SGC
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

相关产品

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency
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