SML1135
MG-132（R）
≥95% (HPLC), membrane-permeable proteasome inhibitor, powder
别名:
ZL-LEU-d-LEU-L-LEU-al
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关于此项目
经验公式（希尔记法）:
C26H41N3O5
化学文摘社编号:
分子量:
475.62
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
MG-132（R）, ≥95% (HPLC)
product line
SAFC Hitech®
Quality Level
assay
≥95% (HPLC)
form
powder
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O
InChI
1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
InChI key
TZYWCYJVHRLUCT-ZRBLBEILSA-N
Gene Information
human ... CTSB(1508), NFKB1(4790), PSMA1(5682)
Biochem/physiol Actions
MG-132（R）是一种有效的膜透性蛋白酶体抑制剂。以10μM的浓度，它诱导PC12细胞中的神经突向外生长。BXI-132(R)可阻断聚（ADP-核糖）聚合酶的切割和胸腺细胞的凋亡。然而，MG-132（R）还可激活c-Jun N-末端蛋白激酶（JNK-1），其可响应细胞应激而启动细胞凋亡。蛋白酶体抑制可诱导热休克蛋白mRNA的积累、热休克蛋白的激活、以及增强各种细胞类型中的耐热性。
Legal Information
SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xueyan Zhao et al.
Developmental and comparative immunology, 106, 103632-103632 (2020-01-29)
Tightly regulation of NF-κB signaling is essential to innate and adaptive immune responses, but its regulatory mechanism remains unclear in various organisms, especially teleost fish. In this study, we reported that IRF3 attenuates the inhibitory effect of IκBα on NF-κB
Yalong Wang et al.
Neuroscience letters, 739, 135402-135402 (2020-09-26)
Synaptotagmin-11 (Syt11) is associated with schizophrenia and Parkinson's disease (PD) and is a critical substrate of parkin, an E3 ubiquitin ligase linked to PD. Previously we reported that Syt11 regulates multiple membrane trafficking pathways in neurons and glia. However, the
Corinna Wentzel et al.
Nature communications, 9(1), 267-267 (2018-01-20)
Here we explore the relationship between presynaptic homeostatic plasticity and proteasome function at the Drosophila neuromuscular junction. First, we demonstrate that the induction of homeostatic plasticity is blocked after presynaptic proteasome perturbation. Proteasome inhibition potentiates release under baseline conditions but
The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.
Han YH
Oncology Reports, 22(1), 215-221 (2009)
Fanjie Jin et al.
Oncology letters, 19(1), 858-868 (2020-01-04)
The clinical significance of the proteasome inhibitor MG132 has been examined in numerous human cancer types; however, its influence on the metastasis and progression of pancreatic cancer is yet to be determined. In the present study, the effect of MG132
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1135-5MG | 04061837107627 |
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