SML1169
Pitstop 2
≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor
别名:
N-[5-[（4-溴苯基）亚甲基]-4,5-二氢-4-氧代-2-噻唑基]-1-萘磺酰胺, Pitstop-2
产品名称
Pitstop 2, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 20 mg/mL, clear
储存温度
−20°C
应用
Pitstop 2 已被用作网格蛋白介导内吞作用的抑制剂。
生化/生理作用
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂。
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂，通过阻断配体进入网格蛋白末端结构域发挥作用。Pitstop 2 能选择性抑制网格蛋白介导的 HIV 进入，并阻止网格蛋白包覆的pit (CCP) 动力学。
Pitstop 2 还具有破坏核孔复合体 (NPC) 通透性屏障和降低输入蛋白 β结合，同时改变 NPC 超微结构。Pitstop 2 还参与抑制血小板活化、血小板聚集和分泌。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
Scientific Reports, 5, 9994-9994 (2015)
Muhammad Asam Riaz et al.
Journal of proteomics, 227, 103918-103918 (2020-07-28)
Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was
Leucine-rich repeat-containing G protein?coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Zhang N, et al,
The Journal of Biological Chemistry, 292(40), 16527-16538 (2017)
Clathrin-mediated integrin ?IIb?3 trafficking controls platelet spreading
Gao W, et al.
Platelets, 1-12 (2017)
Maria S Ioannou et al.
Cell, 177(6), 1522-1535 (2019-05-28)
Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive
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