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SML1169

Sigma-Aldrich

Pitstop 2

≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor

别名:

N-[5-[(4-溴苯基)亚甲基]-4,5-二氢-4-氧代-2-噻唑基]-1-萘磺酰胺, Pitstop-2

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5 MG
¥1,004.58
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目录价¥1,435.12节省 30%

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5 MG
¥1,004.58
25 MG
¥5,784.39

About This Item

经验公式(希尔记法):
C20H13BrN2O3S2
CAS Number:
分子量:
473.36
UNSPSC代码:
12352200
NACRES:
NA.77

¥1,004.58

目录价¥1,435.12节省 30%

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Product Name

Pitstop 2, ≥98% (HPLC)

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to light brown

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

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此商品
S5951SML2226SML0493
Pitstop 2 ≥98% (HPLC)

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SW02

S5951

SW02

BC-LI-0186 ≥98% (HPLC)

SML2226

BC-LI-0186

T16Ainh-A01 ≥95% (HPLC)

SML0493

T16Ainh-A01

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to light brown

color

white to off-white

color

white to beige

color

white to beige

应用

Pitstop 2 已被用作网格蛋白介导内吞作用的抑制剂。[1][2]

生化/生理作用

Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂。
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂,通过阻断配体进入网格蛋白末端结构域发挥作用。Pitstop 2 能选择性抑制网格蛋白介导的 HIV 进入,并阻止网格蛋白包覆的pit (CCP) 动力学。
Pitstop 2 还具有破坏核孔复合体 (NPC) 通透性屏障和降低输入蛋白 β结合,同时改变 NPC 超微结构。[3]Pitstop 2 还参与抑制血小板活化、血小板聚集和分泌。[4]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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