SML1169
Pitstop 2
≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor
别名:
N-[5-[（4-溴苯基）亚甲基]-4,5-二氢-4-氧代-2-噻唑基]-1-萘磺酰胺, Pitstop-2
产品名称
Pitstop 2, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Pitstop 2 已被用作网格蛋白介导内吞作用的抑制剂。
Biochem/physiol Actions
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂。
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂，通过阻断配体进入网格蛋白末端结构域发挥作用。Pitstop 2 能选择性抑制网格蛋白介导的 HIV 进入，并阻止网格蛋白包覆的pit (CCP) 动力学。
Pitstop 2 还具有破坏核孔复合体 (NPC) 通透性屏障和降低输入蛋白 β结合，同时改变 NPC 超微结构。Pitstop 2 还参与抑制血小板活化、血小板聚集和分泌。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Clathrin-mediated integrin ?IIb?3 trafficking controls platelet spreading
Gao W, et al.
Platelets, 1-12 (2017)
Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
Scientific Reports, 5, 9994-9994 (2015)
Leucine-rich repeat-containing G protein?coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Zhang N, et al,
The Journal of Biological Chemistry, 292(40), 16527-16538 (2017)
Muhammad Asam Riaz et al.
Journal of proteomics, 227, 103918-103918 (2020-07-28)
Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was
Meagan M Postema et al.
Molecular biology of the cell, 30(19), 2515-2526 (2019-08-08)
Apical microvilli are critical for the homeostasis of transporting epithelia, yet mechanisms that control the assembly and morphology of these protrusions remain poorly understood. Previous studies in intestinal epithelial cell lines suggested a role for the F-BAR domain protein PACSIN2
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