SML1271
TWS119
≥98% (HPLC)
别名:
3-[6-(3-氨基苯基)-7H-吡咯并[2,3-d]嘧啶-4-基氧基]苯酚
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关于此项目
经验公式（希尔记法）:
C18H14N4O2
化学文摘社编号:
分子量:
318.33
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
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相关类别
应用
TWS119已被用作糖原合酶激酶3β（GSK-3β）GSK3β抑制剂。
生化/生理作用
TWS119可通过激活哺乳动物雷帕霉素靶标（mTOR）途径促进γδT细胞的存活和增殖。它还可以促进T细胞因子1（TCF1）的表达并调节细胞因子的生成。
TWS119是一种可以诱导胚胎干细胞（ESC）中神经生成的有效糖原合酶激酶3β（GSK-3β）抑制剂。
TWS119是一种有效的糖原合成酶激酶-3 β(GSK-3β) 抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Limin Gao et al.
Neuroreport, 35(3), 200-207 (2024-02-02)
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis
Nurr1: A vital participant in the TLR4-NF-kappaB signal pathway stimulated by alpha-synuclein in BV-2 cells
Shao QH, et al.
Neuropharmacology, 144, 388-399 (2019)
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer
Chen YQ, et al.
Experimental Cell Research, 362(1), 63-71 (2018)
Effects of Glycogen Synthase Kinase-3beta Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer
Tang YY, et al.
Journal of Immunotherapy, 41(7), 319-319 (2018)
Yeonhwa Song et al.
Scientific reports, 14(1), 115-115 (2024-01-04)
Hepatocellular carcinoma (HCC) is a complex disease associated with a plethora of environmental and genetic/hereditary causative risk factors, more so than other oncological indications. Additionally, patients with HCC exhibit fibrosis, cirrhosis, and liver-related disease. This complicated etiology can affect the
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