SML1271
TWS119
≥98% (HPLC)
别名:
3-[6-(3-氨基苯基)-7H-吡咯并[2,3-d]嘧啶-4-基氧基]苯酚
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关于此项目
经验公式（希尔记法）:
C18H14N4O2
化学文摘社编号:
分子量:
318.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
SMILES string
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
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相关类别
Application
TWS119已被用作糖原合酶激酶3β（GSK-3β）GSK3β抑制剂。
Biochem/physiol Actions
TWS119可通过激活哺乳动物雷帕霉素靶标（mTOR）途径促进γδT细胞的存活和增殖。它还可以促进T细胞因子1（TCF1）的表达并调节细胞因子的生成。
TWS119是一种可以诱导胚胎干细胞（ESC）中神经生成的有效糖原合酶激酶3β（GSK-3β）抑制剂。
TWS119是一种有效的糖原合成酶激酶-3 β(GSK-3β) 抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
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Limin Gao et al.
Neuroreport, 35(3), 200-207 (2024-02-02)
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis
Effects of Glycogen Synthase Kinase-3beta Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer
Tang YY, et al.
Journal of Immunotherapy, 41(7), 319-319 (2018)
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer
Chen YQ, et al.
Experimental Cell Research, 362(1), 63-71 (2018)
Chen Chen et al.
International immunopharmacology, 85, 106577-106577 (2020-05-24)
Chemokine-like factor 1 (CKLF1) is a chemokine increased significantly in ischemic brain poststroke. It shows chemotaxis effects on various immune cells, but the mechanisms of CKLF1 migrating neutrophils are poorly understood. Recent studies have provided evidence that CC chemokine receptor
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