SML1271
TWS119
≥98% (HPLC)
别名:
3-[6-(3-氨基苯基)-7H-吡咯并[2,3-d]嘧啶-4-基氧基]苯酚
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关于此项目
经验公式（希尔记法）:
C18H14N4O2
化学文摘社编号:
分子量:
318.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Application
TWS119已被用作糖原合酶激酶3β（GSK-3β）GSK3β抑制剂。
Biochem/physiol Actions
TWS119可通过激活哺乳动物雷帕霉素靶标（mTOR）途径促进γδT细胞的存活和增殖。它还可以促进T细胞因子1（TCF1）的表达并调节细胞因子的生成。
TWS119是一种可以诱导胚胎干细胞（ESC）中神经生成的有效糖原合酶激酶3β（GSK-3β）抑制剂。
TWS119是一种有效的糖原合成酶激酶-3 β(GSK-3β) 抑制剂。
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存储类别
11 - Combustible Solids
wgk
WGK 3
Effects of Glycogen Synthase Kinase-3beta Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer
Tang YY, et al.
Journal of Immunotherapy, 41(7), 319-319 (2018)
Limin Gao et al.
Neuroreport, 35(3), 200-207 (2024-02-02)
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis
Nurr1: A vital participant in the TLR4-NF-kappaB signal pathway stimulated by alpha-synuclein in BV-2 cells
Shao QH, et al.
Neuropharmacology, 144, 388-399 (2019)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1271-25MG | 04061832434827 |
| SML1271-5MG | 04061832434834 |